Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSL1 | P33121 | 2/20 | 0.56 |
| ▸ | ACSL6 | Q9UKU0 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 8/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7397081 | 1.00 | ACSL1 (0.56) | ACSL1ACSL6LMNAMAOBHRH3 | |
| SCHEMBL5390554 | 0.94 | LMNA (0.58) | ACSL1ACSL6LMNAMAOBHRH3 | |
| SCHEMBL10090173 | 0.89 | LMNA (0.60) | ACSL1ACSL6LMNAMAOBHRH3 | |
| SCHEMBL7443404 | 0.87 | ACSL1 (0.48) | ACSL1ACSL6LMNAMAOBHRH3 | |
| SCHEMBL5579221 | 0.82 | LMNA (0.62) | ACSL1ACSL6LMNAMAOBHRH3 | |
| SCHEMBL16806176 | 0.81 | LMNA (0.60) | ACSL1ACSL6LMNAMAOBHRH3 | |
| SCHEMBL9870777 | 0.80 | LMNA (0.60) | ACSL1ACSL6LMNAMAOBHRH3 | |
| SCHEMBL10090415 | 0.80 | LMNA (0.64) | ACSL1ACSL6LMNAMAOBHRH3 | |
| SCHEMBL10090166 | 0.79 | LMNA (0.61) | ACSL1ACSL6LMNAMAOBHRH3 | |
| SCHEMBL11843741 | 0.78 | ACSL1 (0.50) | ACSL1ACSL6LMNAMAOBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710237-A1 | QUINOLIZIDINES WITH CALCIUM CHANNEL ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-05-08 | — | — | EP | disclosed |
| WO-1995003302-A1 | QUINOLIZIDINES WITH CALCIUM CHANNEL ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-02-02 | — | — | WO | disclosed |