SCHEMBL740549

SCHEMBL740549

NC(=O)c1ccc(C=NO)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.67
ACHE P22303 4/20 0.60
L3MBTL1 Q9Y468 2/20 0.55
KDM4E B2RXH2 1/20 0.55
ESRRG P62508 1/20 0.50
MAPT P10636 3/20 0.49
GFER P55789 1/20 0.49
PARP10 Q53GL7 3/20 0.48
PARP3 Q9Y6F1 1/20 0.48
RAB9A P51151 3/20 0.47
PARP4 Q9UKK3 2/20 0.45
ALDH1A1 P00352 1/20 0.45
PARP15 Q460N3 1/20 0.45
PARP14 Q460N5 1/20 0.45
PARP16 Q8N5Y8 1/20 0.45
PARP11 Q9NR21 1/20 0.45
PARP1 P09874 2/20 0.44
F2 P00734 1/20 0.44
POLB P06746 1/20 0.44
CYP3A4 P08684 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8224874 1.00 KMT2A (0.67) KMT2AACHEL3MBTL1KDM4EESRRG
SCHEMBL2163478 0.80 KMT2A (1.00) KMT2AL3MBTL1KDM4EMAPTGFER
SCHEMBL2229059 0.80 KMT2A (1.00) KMT2AL3MBTL1KDM4EMAPTGFER
SCHEMBL2163477 0.80 KMT2A (1.00) KMT2AL3MBTL1KDM4EMAPTGFER
SCHEMBL9938969 0.78 KDM1A (0.60) KMT2AACHEL3MBTL1KDM4EMAPT
SCHEMBL21215365 0.78 KDM1A (0.60) KMT2AACHEL3MBTL1KDM4EMAPT
SCHEMBL9938975 0.78 KDM1A (0.60) KMT2AACHEL3MBTL1KDM4EMAPT
SCHEMBL4275683 0.78 KMT2A (0.64) KMT2AACHEL3MBTL1KDM4EMAPT
SCHEMBL27198359 0.78 KMT2A (0.64) KMT2AACHEL3MBTL1KDM4EMAPT
SCHEMBL5668373 0.78 KMT2A (0.64) KMT2AACHEL3MBTL1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4387451-A1 ORAL FELINE FEED AND METHODS FOR CONTROLLING TICK INFESTATIONS IN A FELINE In the Bowl Animal Health, Inc. (US) 2024-06-26 EP disclosed
US-20240165085-A1 ORAL FELINE FEED AND METHODS FOR CONTROLLING TICK INFESTATIONS IN A FELINE IN THE BOWL ANIMAL HEALTH, INC. 2024-05-23 US disclosed
US-20240156789-A1 ORAL FELINE FEED AND METHODS FOR CONTROLLING FLEA INFESTATIONS IN A FELINE IN THE BOWL ANIMAL HEALTH, INC. 2024-05-16 US disclosed
EP-4358737-A2 ORAL FELINE FEED AND METHODS FOR CONTROLLING FLEA INFESTATIONS IN A FELINE In the Bowl Animal Health, Inc. (US) 2024-05-01 EP disclosed
CN-117915782-A Oral feed for felines and method for controlling flea infestations in felines 碗中动物健康公司 2024-04-19 CN disclosed
CN-117769356-A Oral feed for felines and method for controlling tick infestations in felines 碗中动物健康公司 2024-03-26 CN disclosed
CN-117500498-A Method for controlling flea and tick infestations in mammals 碗中动物健康公司 2024-02-02 CN disclosed
EP-4304722-A1 METHODS FOR CONTROLLING FLEA AND TICK INFESTATIONS IN A MAMMAL In the Bowl Animal Health, Inc. (US) 2024-01-17 EP disclosed
EP-4304357-A1 ORAL CANINE FEED AND METHODS FOR CONTROLLING TICK INFESTATIONS IN A CANINE In the Bowl Animal Health, Inc. (US) 2024-01-17 EP disclosed
EP-4304356-A1 ORAL CANINE FEED AND METHODS FOR CONTROLLING FLEA INFESTATIONS IN A CANINE In the Bowl Animal Health, Inc. (US) 2024-01-17 EP disclosed
US-8138213-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2012-03-20 US disclosed
US-20110251398-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-10-13 US disclosed
US-8022089-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-09-20 US disclosed
US-20110144334-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-06-16 US disclosed
US-7951828-B1 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-05-31 US disclosed
US-7662972-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-02-16 US disclosed
US-20090312330-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-12-17 US disclosed
EP-1932836-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND HARMFUL ORGANISM-CONTROLLING AGENT Nissan Chemical Industries, Ltd. (JP) 2008-06-18 EP disclosed
US-20070066617-A1 Insecticidal and acaricidal activity for many agricultural insect pests, spider mites; endo- or ecto-parasiticide for mammals or birds; veterinary medicine; environmentally friendly NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2007-03-22 US disclosed
EP-1731512-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND NOXIOUS ORGANISM CONTROL AGENT Nissan Chemical Industries, Ltd. (JP) 2006-12-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110144334-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE OR10J3, OR51E2, ORMDL3 KMT2A 2143/4885ACHE 198/4885L3MBTL1 882/4885
US-20240156789-A1 ORAL FELINE FEED AND METHODS FOR CONTROLLING FLEA INFESTATIONS IN A FELINE CAT, F7, PIGO KMT2A 1024/4885ACHE 66/4885L3MBTL1 2270/4885
US-20090312330-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE ATM, CHRM1, NAT1 KMT2A 1871/4885ACHE 24/4885L3MBTL1 818/4885
US-20240165085-A1 ORAL FELINE FEED AND METHODS FOR CONTROLLING TICK INFESTATIONS IN A FELINE CAT, F7, PIGO KMT2A 1013/4885ACHE 250/4885L3MBTL1 3279/4885
US-20110251398-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE CBR3, CHRM1, CBR1 KMT2A 3427/4885ACHE 238/4885L3MBTL1 910/4885
US-20070066617-A1 Insecticidal and acaricidal activity for many agricultural insect pests, spider mites; endo- or ecto-parasiticide for mammals or birds; veterinary medicine; environmentally friendly CHRM1, DDT, ATM KMT2A 3861/4885ACHE 22/4885L3MBTL1 200/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.