Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2163478 | 1.00 | KMT2A (1.00) | KMT2AALDH1A1CA2CA1TP53 | |
| SCHEMBL2229059 | 1.00 | KMT2A (1.00) | KMT2AALDH1A1CA2CA1TP53 | |
| SCHEMBL19757214 | 0.84 | KMT2A (0.72) | KMT2AALDH1A1CA2CA1TP53 | |
| SCHEMBL8224874 | 0.80 | KMT2A (0.67) | KMT2AALDH1A1CA2CA1TSHR | |
| SCHEMBL740549 | 0.80 | KMT2A (0.67) | KMT2AALDH1A1CA2CA1TSHR | |
| SCHEMBL6847518 | 0.80 | KMT2A (0.67) | KMT2AALDH1A1CA2CA1TP53 | |
| SCHEMBL17273591 | 0.80 | KMT2A (0.67) | KMT2AALDH1A1CA2CA1TP53 | |
| SCHEMBL20787422 | 0.80 | KMT2A (0.67) | KMT2AALDH1A1CA2CA1TP53 | |
| SCHEMBL27198359 | 0.80 | KMT2A (0.64) | KMT2AALDH1A1MAPTRAB9AKDM4E | |
| SCHEMBL4275683 | 0.80 | KMT2A (0.64) | KMT2AALDH1A1MAPTRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-57053440-A | — | — | None | — | — | JP | disclosed |
| JP-57053441-A | — | — | None | — | — | JP | disclosed |
| CN-114539180-A | Isoxazoline-containing bisamide compound and preparation method and application thereof | 贵州大学 | 2022-05-27 | — | — | CN | disclosed |
| EP-2524909-B1 | PREPARATION METHOD OF 4-AMINOMETHYLBENZOIC ACID | NAF CO LTD (KR) | 2015-03-18 | — | — | EP | disclosed |
| US-8907127-B2 | Preparation method of 4-aminomethylbenzoic acid | NAF CO LTD (KR) | 2014-12-09 | — | — | US | disclosed |
| EP-2366704-B1 | Inhibitors of serine proteases | VERTEX PHARMA (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-2631238-A1 | Spirocyclic inhibitors of serine proteases for the treatment of hcv infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-08-28 | — | — | EP | disclosed |
| US-20120296114-A1 | PREPARATION METHOD OF 4-AMINOMETHYLBENZOIC ACID | SK PETROCHEMICAL CO., LTD. (KR) | 2012-11-22 | — | — | US | disclosed |
| EP-2524909-A2 | PREPARATION METHOD OF 4-AMINOMETHYLBENZOIC ACID | NAF Co., Ltd. (KR) | 2012-11-21 | — | — | EP | disclosed |
| EP-1917269-B1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMA (US) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366704-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-21 | — | — | EP | disclosed |
| EP-2364984-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-14 | — | — | EP | disclosed |
| US-7985762-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-26 | — | — | US | disclosed |
| US-20110165120-A1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-07 | — | — | US | disclosed |
| EP-0826660-B1 | Non-hygroscopic crystals of p-aminomethylbenzoic acid and process for preparing the same | SHOWA DENKO KK (JP) | 2002-04-03 | — | — | EP | disclosed |
| US-5777158-A | Non-hygroscopic crystals of p-aminomethylbenzoic acid and process for preparing the same | SHOWA DENKO K.K. (JP) | 1998-07-07 | — | — | US | disclosed |
| EP-0826660-A1 | Non-hygroscopic crystals of p-aminomethylbenzoic acid and process for preparing the same | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1998-03-04 | — | — | EP | disclosed |
| JP-S5753441-A | PREPARATION OF 4-AMINOMETHYLBENZOIC ACID | KUREHA CHEM IND CO LTD | 1982-03-30 | — | — | JP | disclosed |
| JP-S5753440-A | PREPARATION OF 4-AMINOMETHYLCYCLOHEXANECARBOXYLIC ACID AND ITS MINERAL ACID SALT | KUREHA CHEM IND CO LTD | 1982-03-30 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110165120-A1 | INHIBITORS OF SERINE PROTEASES | PRSS1, PRSS3, PRSS2 | KMT2A 3222/4885ALDH1A1 1374/4885CA2 1981/4885 |
| US-20120296114-A1 | PREPARATION METHOD OF 4-AMINOMETHYLBENZOIC ACID | HAAO, ALKBH3, HAO2 | KMT2A 176/4885ALDH1A1 508/4885CA2 384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.