Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.65 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.65 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.65 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.65 |
| ▸ | HTR3B | O95264 | 1/20 | 0.65 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.65 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.65 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.65 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.65 |
| ▸ | HTR3A | P46098 | 1/20 | 0.65 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.65 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.65 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.65 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7405686 | 1.00 | CYP3A4 (0.65) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Maleic Acid SCHEMBL7407965 | 0.98 | CYP3A4 (0.65) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Fumaric Acid SCHEMBL7407973 | 0.98 | CYP3A4 (0.65) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| SCHEMBL9837125 | 0.93 | CYP3A4 (0.74) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| SCHEMBL7408093 | 0.92 | CYP3A4 (0.72) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| SCHEMBL9835755 | 0.91 | CYP3A4 (0.74) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| SCHEMBL9834638 | 0.90 | CYP3A4 (0.76) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Fumaric Acid SCHEMBL7416156 | 0.89 | CYP3A4 (0.68) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Maleic Acid SCHEMBL7416149 | 0.89 | CYP3A4 (0.68) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Hydrochloric Acid SCHEMBL7407971 | 0.89 | CYP3A4 (0.75) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4695578-A | 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances | GLAXO GROUP LIMITED (GB) | 1987-09-22 | — | — | US | disclosed |
| EP-0191562-A2 | Tetrahydrocarbazolone derivatives | GLAXO GROUP LIMITED (GB) | 1986-08-20 | — | — | EP | disclosed |