Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 12/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371156 | 0.92 | HTT (0.57) | TACR2EGFRALDH1A1HTT | |
| SCHEMBL7365328 | 0.91 | NPC1 (0.56) | TACR2EGFREPHX2ALDH1A1HTT | |
| SCHEMBL7341842 | 0.91 | NPC1 (0.56) | TACR2EGFREPHX2ALDH1A1HTT | |
| SCHEMBL7404532 | 0.90 | TACR2 (0.53) | TACR2HTT | |
| SCHEMBL7287023 | 0.89 | MEN1 (0.60) | TACR2LMNAKMT2A | |
| SCHEMBL12310426 | 0.89 | MEN1 (0.60) | TACR2LMNAKMT2A | |
| SCHEMBL7370861 | 0.85 | TACR2 (0.56) | TACR2EGFREPHX2MAPTLMNA | |
| SCHEMBL7344537 | 0.85 | TACR2 (0.64) | TACR2 | |
| SCHEMBL3581847 | 0.82 | MEN1 (0.51) | TACR2LMNAALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL5601506 | 0.82 | TACR2 (0.67) | TACR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117841-A | USED TO TREAT STROKE, CEREBRAL ISCHEMIA, PAIN, HEAD TRAUMA OR EPILEPSY | WARNER-LAMBERT COMPANY (US) | 2000-09-12 | — | — | US | claimed |
| WO-1998054123-A1 | SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS | WARNER-LAMBERT COMPANY (US) | 1998-12-03 | — | — | WO | claimed |
| US-6117841-A | USED TO TREAT STROKE, CEREBRAL ISCHEMIA, PAIN, HEAD TRAUMA OR EPILEPSY | WARNER-LAMBERT COMPANY (US) | 2000-09-12 | — | — | US | disclosed |
| WO-1998054123-A1 | SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS | WARNER-LAMBERT COMPANY (US) | 1998-12-03 | — | — | WO | disclosed |