SCHEMBL7365328

SCHEMBL7365328

N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)NCCN1CCCCC1

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.56
RAB9A P51151 3/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
HRH3 Q9Y5N1 5/20 0.56
HTT P42858 2/20 0.56
KDM4E B2RXH2 3/20 0.55
EGFR P00533 2/20 0.55
ALDH1A1 P00352 2/20 0.55
NPY1R P25929 1/20 0.55
DPP7 Q9UHL4 1/20 0.55
NPSR1 Q6W5P4 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
LTA4H P09960 1/20 0.52
EPHX2 P34913 1/20 0.52
TACR2 P21452 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7341842 1.00 NPC1 (0.56) NPC1RAB9ASMN1; SMN2HRH3HTT
SCHEMBL7371156 0.99 HTT (0.57) NPC1RAB9ASMN1; SMN2HRH3HTT
SCHEMBL7404532 0.91 TACR2 (0.53) HTTDPP7LTA4HTACR2
SCHEMBL7405696 0.91 TACR2 (0.62) HTTEGFRALDH1A1EPHX2TACR2
SCHEMBL7339423 0.90 TACR2 (0.55) NPC1RAB9ASMN1; SMN2HRH3HTT
SCHEMBL7336892 0.88 TACR2 (0.54) NPC1RAB9ASMN1; SMN2HRH3HTT
SCHEMBL5417001 0.88 RAB9A (0.61) RAB9ADPP7
SCHEMBL5417009 0.88 RAB9A (0.61) RAB9ADPP7
SCHEMBL7337508 0.85 CTSS (0.55) NPC1RAB9ASMN1; SMN2TACR2
SCHEMBL7344798 0.84 TACR2 (0.53) NPC1RAB9ASMN1; SMN2DPP7TACR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6323243-B1 AROMATIC ETHER WITH AMINE OR AMIDE GROUPS WARNER-LAMBERT COMPANY 2001-11-27 US disclosed
US-6180677-B1 ANTIEPILEPSY AGENT WARNER-LAMBERT COMPANY 2001-01-30 US disclosed
US-6117841-A USED TO TREAT STROKE, CEREBRAL ISCHEMIA, PAIN, HEAD TRAUMA OR EPILEPSY WARNER-LAMBERT COMPANY (US) 2000-09-12 US disclosed
WO-2000006535-A1 TYROSINE-DERIVED COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS WARNER-LAMBERT COMPANY (US) 2000-02-10 WO disclosed
WO-1998054123-A1 SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS WARNER-LAMBERT COMPANY (US) 1998-12-03 WO disclosed