SCHEMBL7405992

SCHEMBL7405992

CC(C)(C)OC(=O)N[C@H](CCCOCc1ccccc1)C(=O)O

nearest known ligand 0.71

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 5/20 0.71
PPARG P37231 4/20 0.65
CTSS P25774 3/20 0.57
CTSK P43235 3/20 0.55
ACE P12821 1/20 0.54
PPARD Q03181 2/20 0.50
ALDH1A1 P00352 1/20 0.50
TSHR P16473 1/20 0.50
FOLH1 Q04609 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7442052 1.00 PPARA (0.71) PPARAPPARGCTSSCTSKACE
SCHEMBL27897229 1.00 PPARA (0.71) PPARAPPARGCTSSCTSKACE
SCHEMBL8615711 0.96 PPARA (0.69) PPARAPPARGCTSSCTSKACE
SCHEMBL955526 0.93 PPARA (0.74) PPARAPPARGCTSSCTSKACE
SCHEMBL1312604 0.93 PPARA (0.74) PPARAPPARGCTSSCTSKACE
SCHEMBL955527 0.93 PPARA (0.74) PPARAPPARGCTSSCTSKACE
SCHEMBL12521758 0.91 PPARA (0.65) PPARAPPARGCTSSCTSKACE
SCHEMBL18555200 0.90 PPARA (0.78) PPARAPPARGCTSSCTSKACE
SCHEMBL18555201 0.90 PPARA (0.78) PPARAPPARGCTSSCTSKACE
SCHEMBL28040934 0.90 PPARA (0.59) PPARAPPARGCTSSCTSKACE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0615977-B1 Spiro piperidines and homologs which promote release of growth hormone MERCK & CO INC (US) 2002-07-03 EP disclosed
US-6313133-B1 ORALLY ADMINISTERING AN EFFECTIVE AMOUNT OF A GROWTH HORMONE SECRETAGOGUE FOR ENHANCING QUALITY OF SLEEP IN MAMMAL ARCH DEVELOPMENT CORPORATION 2001-11-06 US disclosed
US-6123964-A N-(1(R)-((1,2-DIHYDRO-1-METHANESULFONYLSPIRO(3H-INDOLE-3,4' -PIPERDIN)-1'-YL)CARBONYL)-2-(PHENYLMETHYLOXY)ETHYL)-2-AMINO-2-METHYL -PROPANAMIDE, SPECIFIED BINDER/DILUENT, FIRST AND SECOND DILUENTS, DISINTEGRANT, AND LUBRICANT(S); TABLETS MERCK & CO., INC. (US) 2000-09-26 US disclosed
EP-1019402-A1 POLYMORPHIC FORMS OF A GROWTH HORMONE SECRETAGOGUE Merck & Co., Inc. (US) 2000-07-19 EP disclosed
US-6071926-A TREATING SLEEP DISORDERS CAUSED BY DEFICIENCIES OF GROWTH HORMONES OR PROLACTIN, GERONTOLOGY ARCH DEVELOPMENT CORPORATION (US) 2000-06-06 US disclosed
EP-0900086-A4 ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE MERCK & CO INC (US) 2000-01-12 EP disclosed
EP-0813414-A4 COMBINATION OF BISPHOSPHONATES AND GROWTH HORMONE SECRETAGOGUES MERCK & CO INC (US) 1999-07-21 EP disclosed
EP-0900086-A1 ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE Merck & Co., Inc. (US) 1999-03-10 EP disclosed
EP-0857020-A4 WET GRANULATION FORMULATION OF A GROWTH HORMONE SECRETAGOGUE MERCK & CO INC (US) 1999-01-07 EP disclosed
EP-0857020-A1 WET GRANULATION FORMULATION OF A GROWTH HORMONE SECRETAGOGUE Merck & Co., Inc. (US) 1998-08-12 EP disclosed
EP-0813414-A1 COMBINATION OF BISPHOSPHONATES AND GROWTH HORMONE SECRETAGOGUES MERCK & CO. INC. (US) 1997-12-29 EP disclosed
WO-1997041879-A1 ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE MERCK & CO., INC. (US) 1997-11-13 WO disclosed
WO-1997041878-A1 TREATMENT OF MOOD DISORDERS WITH A GROWTH HORMONE SECRETAGOGUE MERCK & CO., INC. (US) 1997-11-13 WO disclosed
US-5652235-A Method of using spiro piperidines to promote the release of growth hormone MERCK & CO., INC. (US) 1997-07-29 US disclosed
WO-1997015191-A1 WET GRANULATION FORMULATION OF A GROWTH HORMONE SECRETAGOGUE MERCK & CO., INC. (US) 1997-05-01 WO disclosed
WO-1997015574-A1 POLYMORPHIC FORMS OF A GROWTH HORMONE SECRETAGOGUE MERCK & CO., INC. (US) 1997-05-01 WO disclosed
US-5536716-A Spiro piperidines and homologs which promote release of growth hormone MERCK & CO., INC. (US) 1996-07-16 US disclosed
WO-1995011029-A1 COMBINATION OF BISPHOSPHONATES AND GROWTH HORMONE SECRETAGOGUES MERCK & CO., INC. (US) 1995-04-27 WO disclosed
EP-0615977-A1 Spiro piperidines and homologs which promote release of growth hormone MERCK & CO. INC. (US) 1994-09-21 EP disclosed
WO-1994013696-A1 SPIRO PIPERIDINES AND HOMOLOGS WHICH PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-06-23 WO disclosed