Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 17/20 | 0.62 |
| ▸ | DPP8 | Q6V1X1 | 9/20 | 0.62 |
| ▸ | DPP7 | Q9UHL4 | 8/20 | 0.62 |
| ▸ | DPP9 | Q86TI2 | 8/20 | 0.62 |
| ▸ | FAP | Q12884 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7029434 | 1.00 | DPP4 (0.62) | DPP4DPP8DPP7DPP9FAP | |
| SCHEMBL542217 | 0.84 | DPP4 (0.61) | DPP4DPP8DPP7DPP9FAP | |
| SCHEMBL7312802 | 0.83 | DPP4 (0.73) | DPP4DPP8DPP7DPP9FAP | |
| SCHEMBL9840411 | 0.83 | DPP4 (0.73) | DPP4DPP8DPP7DPP9FAP | |
| SCHEMBL7312806 | 0.83 | DPP4 (0.73) | DPP4DPP8DPP7DPP9FAP | |
| SCHEMBL17456229 | 0.82 | DPP4 (0.50) | DPP4DPP8DPP7DPP9FAP | |
| SCHEMBL7172842 | 0.81 | DPP4 (0.56) | DPP4DPP8DPP7DPP9FAP | |
| SCHEMBL29058389 | 0.80 | DPP4 (0.48) | DPP4DPP8DPP7DPP9FAP | |
| SCHEMBL2769140 | 0.80 | DPP4 (0.75) | DPP4DPP8DPP7DPP9FAP | |
| SCHEMBL2769136 | 0.80 | DPP4 (0.75) | DPP4DPP8DPP7DPP9FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6468977-B1 | COMPOUNDS USEFUL IN TREATMENT TREATMENT OF DISORDER AND/OR DISEASE CAUSED BY ACTIVITY OF ENZYMES SUCH AS HUMAN RHINOVIRUS 3C PROTEASE, TRANSGLUTAMINASE AND CATHEPSINS | APOTEX INC. (CA) | 2002-10-22 | — | — | US | claimed |
| WO-2001090095-A1 | THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES | APOTEX INC. (CA) | 2001-11-29 | — | — | WO | claimed |
| CN-1291993-A | Thiadiazole compounds useful as cysteine activity dependent enzyme inhibitors | APOTEX INC (CA) | 2001-04-18 | — | — | CN | claimed |
| US-6162791-A | Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes | APOTEX INC. (CA) | 2000-12-19 | — | — | US | claimed |
| EP-1058690-A1 | THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES | APOTEX INC. (CA) | 2000-12-13 | — | — | EP | claimed |
| WO-1999045027-A1 | THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES | APOTEX INC. (CA) | 1999-09-10 | — | — | WO | claimed |
| US-5424292-A | 5-aminosalicylic acid derivatives for the therapy of chronic inflammatory bowel diseases | DEPHA TEAM S.R.L. (IT) | 1995-06-13 | — | — | US | claimed |
| EP-0548177-B1 | 5-AMINOSALICYLIC ACID DERIVATIVES FOR THE THERAPY OF CHRONIC INFLAMMATORY BOWEL DISEASES | DEPHA TEAM SRL (IT) | 1994-05-18 | — | — | EP | claimed |
| EP-0548177-A1 | 5-AMINOSALICYLIC ACID DERIVATIVES FOR THE THERAPY OF CHRONIC INFLAMMATORY BOWEL DISEASES. | DEPHA TEAM SRL (IT) | 1993-06-30 | — | — | EP | claimed |
| WO-1992004369-A1 | 5-AMINOSALICYLIC ACID DERIVATIVES FOR THE THERAPY OF CHRONIC INFLAMMATORY BOWEL DISEASES | DEPHA TEAM S.R.L. (IT) | 1992-03-19 | — | — | WO | claimed |
| US-6468977-B1 | COMPOUNDS USEFUL IN TREATMENT TREATMENT OF DISORDER AND/OR DISEASE CAUSED BY ACTIVITY OF ENZYMES SUCH AS HUMAN RHINOVIRUS 3C PROTEASE, TRANSGLUTAMINASE AND CATHEPSINS | APOTEX INC. (CA) | 2002-10-22 | — | — | US | disclosed |
| WO-2001090095-A1 | THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES | APOTEX INC. (CA) | 2001-11-29 | — | — | WO | disclosed |
| CN-1291993-A | Thiadiazole compounds useful as cysteine activity dependent enzyme inhibitors | APOTEX INC (CA) | 2001-04-18 | — | — | CN | disclosed |
| US-6162791-A | Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes | APOTEX INC. (CA) | 2000-12-19 | — | — | US | disclosed |
| EP-1058690-A1 | THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES | APOTEX INC. (CA) | 2000-12-13 | — | — | EP | disclosed |
| EP-0548177-B1 | 5-AMINOSALICYLIC ACID DERIVATIVES FOR THE THERAPY OF CHRONIC INFLAMMATORY BOWEL DISEASES | DEPHA TEAM SRL (IT) | 1994-05-18 | — | — | EP | disclosed |
| EP-0548177-A1 | 5-AMINOSALICYLIC ACID DERIVATIVES FOR THE THERAPY OF CHRONIC INFLAMMATORY BOWEL DISEASES. | DEPHA TEAM SRL (IT) | 1993-06-30 | — | — | EP | disclosed |
| EP-0548177-A1 | 5-AMINOSALICYLIC ACID DERIVATIVES FOR THE THERAPY OF CHRONIC INFLAMMATORY BOWEL DISEASES. | DEPHA TEAM SRL (IT) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992004369-A1 | 5-AMINOSALICYLIC ACID DERIVATIVES FOR THE THERAPY OF CHRONIC INFLAMMATORY BOWEL DISEASES | DEPHA TEAM S.R.L. (IT) | 1992-03-19 | — | — | WO | disclosed |
| WO-1992004369-A1 | 5-AMINOSALICYLIC ACID DERIVATIVES FOR THE THERAPY OF CHRONIC INFLAMMATORY BOWEL DISEASES | DEPHA TEAM S.R.L. (IT) | 1992-03-19 | — | — | WO | disclosed |