Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | IAPP | P10997 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL7406931 | 0.84 | HPGD (0.46) | HPGDCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL7407879 | 0.84 | SMN1; SMN2 (0.44) | HPGDCYP1A2CYP3A4CYP2C19TRPV1 | |
| Ethylene SCHEMBL7411102 | 0.82 | SMN1; SMN2 (0.43) | HPGDCYP1A2CYP3A4CYP2C19TRPV1 | |
| SCHEMBL13905046 | 0.80 | HPGD (0.50) | HPGDCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL7412813 | 0.79 | TRPV1 (0.45) | HPGDCYP3A4CYP2C19TRPV1ALDH1A1 | |
| SCHEMBL8151785 | 0.79 | HPGD (0.52) | HPGDCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL8217655 | 0.78 | ALDH1A1 (0.52) | HPGDALOX5PTGS2CYP1A2CYP3A4 | |
| SCHEMBL29273227 | 0.78 | PPARA (0.58) | HPGDPPARAALOX5PTGS2ALDH1A1 | |
| SCHEMBL17315857 | 0.77 | CYP3A4 (0.58) | HPGDPPARAALOX5PTGS2CYP1A2 | |
| Ethylene SCHEMBL7414666 | 0.77 | TRPV1 (0.43) | HPGDCYP3A4CYP2C19TRPV1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |