Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EEF2K | O00418 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475686 | 0.81 | KMT2A (0.39) | SLC22A12SLC6A2SLC6A3TP53THRB | |
| SCHEMBL740861 | 0.68 | AKR1C3 (0.35) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL14926951 | 0.61 | ALDH1A1 (0.40) | APPTP53SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL3477086 | 0.61 | ALDH1A1 (0.37) | PTGS2KDM4EMEN1KMT2A | |
| SCHEMBL31240209 | 0.59 | AKR1C3 (0.69) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL1512537 | 0.59 | AKR1C3 (0.69) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL1590709 | 0.59 | AKR1C3 (0.69) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL23692158 | 0.58 | AKR1C3 (0.52) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL9444855 | 0.57 | AKR1C3 (0.65) | AKR1C3AKR1C2PSEN1PSEN2APH1B | |
| SCHEMBL13235896 | 0.56 | AKR1C3 (0.55) | AKR1C3AKR1C2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430029-A1 | THIENO [2, 3-B]PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | Katholieke Universiteit Leuven (BE) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130842-A1 | THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2010-11-18 | — | — | WO | disclosed |