Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409470 | 0.91 | NR1H2 (0.32) | ABCB1 | |
| SCHEMBL7605407 | 0.91 | NR1H2 (0.32) | ABCB1 | |
| SCHEMBL7606288 | 0.91 | NR1H2 (0.32) | ABCB1 | |
| SCHEMBL7405602 | 0.88 | CTSL (0.31) | SMN1; SMN2ABCB1HDAC1MCHR1 | |
| SCHEMBL7460143 | 0.84 | CPB2 (0.32) | — | |
| SCHEMBL7460139 | 0.84 | CPB2 (0.32) | — | |
| SCHEMBL7606294 | 0.81 | CPB2 (0.31) | — | |
| SCHEMBL7605418 | 0.81 | CPB2 (0.31) | — | |
| SCHEMBL7451706 | 0.79 | ABCB1 (0.33) | ABCB1HDAC1CYP3A4 | |
| SCHEMBL7451704 | 0.79 | ABCB1 (0.33) | ABCB1HDAC1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937042-A1 | HETEROARYL SUCCINAMIDES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998017643-A1 | HETEROARYL SUCCINAMIDES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1998-04-30 | — | — | WO | disclosed |