Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
| ▸ | TLR2 | O60603 | 3/20 | 0.32 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | REN | P00797 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762453 | 0.90 | HRH1 (0.39) | RENPOLBBRD4 | |
| Ammonia Solution, Strong SCHEMBL741029 | 0.90 | HRH1 (0.39) | RENPOLBBRD4 | |
| SCHEMBL741030 | 0.78 | HRH1 (0.38) | RENPOLBBRD4 | |
| SCHEMBL763016 | 0.77 | MMP7 (0.41) | — | |
| SCHEMBL742177 | 0.73 | KCNH2 (0.44) | RENPOLBBRD4 | |
| SCHEMBL742179 | 0.73 | HRH1 (0.44) | POLB | |
| SCHEMBL742178 | 0.73 | KCNH2 (0.44) | RENPOLBBRD4 | |
| SCHEMBL764341 | 0.71 | HRH1 (0.41) | PRCPRENPOLB | |
| SCHEMBL762828 | 0.70 | HRH1 (0.41) | PRCPRENPOLB | |
| SCHEMBL762793 | 0.69 | KCNH2 (0.40) | ALDH1A1TSHRPRCPRENPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |