Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.53 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740713 | 1.00 | HRH1 (0.53) | HRH1CHRM1RENNLRP3NOS1 | |
| SCHEMBL739842 | 0.86 | HRH1 (0.70) | HRH1CHRM1RENOPRM1OPRD1 | |
| SCHEMBL739843 | 0.86 | HRH1 (0.70) | HRH1CHRM1RENOPRM1OPRD1 | |
| Piperidine SCHEMBL742276 | 0.84 | HRH1 (0.67) | HRH1CHRM1RENOPRM1OPRD1 | |
| SCHEMBL742774 | 0.83 | HRH1 (0.54) | HRH1CHRM1RENOPRM1OPRD1 | |
| SCHEMBL742773 | 0.83 | HRH1 (0.54) | HRH1CHRM1RENOPRM1OPRD1 | |
| SCHEMBL740755 | 0.83 | HRH1 (0.52) | HRH1CHRM1RENOPRM1OPRD1 | |
| SCHEMBL740756 | 0.83 | HRH1 (0.52) | HRH1CHRM1RENOPRM1OPRD1 | |
| SCHEMBL737976 | 0.83 | HRH1 (0.55) | HRH1CHRM1RENOPRM1OPRD1 | |
| SCHEMBL737977 | 0.83 | HRH1 (0.55) | HRH1CHRM1RENOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |