Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | OGG1 | O15527 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9402319 | 0.86 | HDAC3 (0.48) | SMN1; SMN2MAPTALDH1A1KMT2AGAA | |
| SCHEMBL9402192 | 0.80 | HDAC3 (0.51) | MAPTALDH1A1KMT2AGAAKDM4E | |
| SCHEMBL6509706 | 0.78 | ALDH1A1 (0.55) | SMN1; SMN2MAPTALDH1A1OGG1KMT2A | |
| SCHEMBL9032469 | 0.76 | MAPT (0.40) | SMN1; SMN2MAPTALDH1A1GAARAB9A | |
| SCHEMBL5799993 | 0.75 | SMN1; SMN2 (0.74) | SMN1; SMN2MAPTALDH1A1KMT2AGAA | |
| SCHEMBL6702015 | 0.75 | SMN1; SMN2 (0.74) | SMN1; SMN2MAPTALDH1A1KMT2AGAA | |
| SCHEMBL27177912 | 0.74 | OGG1 (0.65) | SMN1; SMN2MAPTALDH1A1OGG1KMT2A | |
| SCHEMBL12127247 | 0.74 | SMN1; SMN2 (0.72) | SMN1; SMN2MAPTALDH1A1KMT2AGAA | |
| SCHEMBL27177905 | 0.74 | OGG1 (0.65) | SMN1; SMN2MAPTALDH1A1OGG1KMT2A | |
| SCHEMBL27178002 | 0.74 | SMN1; SMN2 (0.76) | SMN1; SMN2MAPTALDH1A1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0515546-A4 | TRIAZOLE ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | — | 1993-05-12 | — | — | EP | disclosed |
| US-5177095-A | Hypotensive agents | MERCK & CO., INC. (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0515546-A1 | TRIAZOLE ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO. INC. (US) | 1992-12-02 | — | — | EP | disclosed |
| WO-1991011909-A1 | TRIAZOLE ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO., INC. (US) | 1991-08-22 | — | — | WO | disclosed |