Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7405536 | 0.93 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPK10CA1CA2 | |
| SCHEMBL7449476 | 0.80 | MAPK10 (0.42) | ALDH1A1LMNAMAPK10CA1CA2 | |
| SCHEMBL7410057 | 0.80 | MAPK10 (0.48) | ALDH1A1LMNAMAPK10CA1CA2 | |
| SCHEMBL7408189 | 0.80 | PLG (0.39) | ALDH1A1LMNAMAPK10CA1CA2 | |
| SCHEMBL7406251 | 0.79 | PLG (0.41) | ALDH1A1LMNAMAPK10CA1CA2 | |
| SCHEMBL7401465 | 0.79 | MAPK10 (0.41) | ALDH1A1LMNAMAPK10CA1CA2 | |
| SCHEMBL7400299 | 0.78 | MAPK10 (0.40) | ALDH1A1LMNAMAPK10CA1CA2 | |
| SCHEMBL7399046 | 0.78 | MAPK10 (0.39) | ALDH1A1LMNAMAPK10CA1CA2 | |
| SCHEMBL7404062 | 0.77 | MAPK10 (0.43) | MAPK10CA1CA2CA7CA9 | |
| SCHEMBL7410608 | 0.77 | MAPK10 (0.36) | ALDH1A1LMNAMAPK10CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002040449-A1 | DIHYDROISOQUINOLINES AS NOVEL PHOSPHODIESTERASE INHIBITORS | ALTANA PHARMA AG (DE) | 2002-05-23 | — | — | WO | disclosed |