Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.38 |
| ▸ | IAPP | P10997 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.37 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.37 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418264 | 0.83 | CYP1A2 (0.57) | ALDH1A1HPGDHSD17B10CYP1A2TDP1 | |
| SCHEMBL1865824 | 0.74 | CASP6 (0.55) | ALDH1A1HPGDHSD17B10CYP1A2TDP1 | |
| SCHEMBL7410546 | 0.74 | TDP1 (0.45) | ALDH1A1HPGDCYP1A2TDP1HCAR3 | |
| SCHEMBL14777639 | 0.73 | TSHR (0.58) | ALDH1A1HPGDHSD17B10CYP1A2TDP1 | |
| SCHEMBL1829346 | 0.73 | TSHR (0.58) | ALDH1A1HPGDHSD17B10CYP1A2TDP1 | |
| SCHEMBL21061856 | 0.73 | CYP1A2 (0.49) | ALDH1A1CYP1A2GSTP1GSTM2KDM4E | |
| SCHEMBL6379699 | 0.71 | GAA (0.59) | ALDH1A1HPGDHSD17B10CYP1A2TDP1 | |
| SCHEMBL15272523 | 0.71 | CYP1A2 (0.71) | ALDH1A1HPGDHSD17B10CYP1A2TDP1 | |
| SCHEMBL1857263 | 0.71 | CA2 (0.59) | ALDH1A1HPGDHSD17B10CYP1A2TDP1 | |
| SCHEMBL2434953 | 0.71 | GAA (0.59) | ALDH1A1HPGDHSD17B10CYP1A2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |