Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459291 | 0.88 | ELANE (0.54) | ELANEF2CTSG | |
| SCHEMBL7406322 | 0.88 | ELANE (0.54) | ELANEF2CTSG | |
| SCHEMBL7459299 | 0.88 | ELANE (0.54) | ELANEF2CTSG | |
| SCHEMBL7404559 | 0.78 | PREP (0.58) | NPSR1 | |
| SCHEMBL6624127 | 0.77 | ELANE (0.50) | ELANEF2CTSG | |
| SCHEMBL6618027 | 0.75 | ELANE (0.50) | ELANEF2CTSG | |
| SCHEMBL7498102 | 0.75 | ELANE (0.50) | ELANEF2CTSG | |
| SCHEMBL6618550 | 0.75 | ELANE (0.54) | ELANEF2CTSG | |
| SCHEMBL7875386 | 0.74 | NPSR1 (0.53) | GRIN2BNPSR1 | |
| SCHEMBL6621333 | 0.74 | ELANE (0.49) | ELANEF2CTSG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015454-A1 | METHOD OF INHIBITING SERINE PROTEASE ENZYMES | GLAXO GROUP LIMITED (GB) | 2000-07-05 | — | — | EP | disclosed |
| EP-0973775-A1 | PYROLOPYRROLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-01-26 | — | — | EP | disclosed |
| WO-1999012932-A1 | METHOD OF INHIBITING SERINE PROTEASE ENZYMES | GLAXO GROUP LIMITED (GB) | 1999-03-18 | — | — | WO | disclosed |
| WO-1998043975-A1 | PYROLOPYRROLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-10-08 | — | — | WO | disclosed |