Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406324 | 0.88 | NPC1 (0.46) | GRIN2BHTTSMN1; SMN2 | |
| SCHEMBL6624131 | 0.80 | NPC1 (0.45) | HTTSMN1; SMN2 | |
| SCHEMBL6618552 | 0.75 | NPC1 (0.44) | HTTSMN1; SMN2 | |
| SCHEMBL7989218 | 0.74 | NPC1 (0.44) | HTTSMN1; SMN2 | |
| SCHEMBL6619994 | 0.74 | NPC1 (0.44) | HTTSMN1; SMN2 | |
| SCHEMBL6617554 | 0.74 | NPC1 (0.44) | HTTSMN1; SMN2 | |
| SCHEMBL6618031 | 0.74 | NPC1 (0.44) | HTTSMN1; SMN2 | |
| SCHEMBL7409091 | 0.70 | MEN1 (0.46) | GRIN2BHSD17B10 | |
| SCHEMBL6621891 | 0.70 | ELANE (0.43) | SMN1; SMN2 | |
| SCHEMBL3047836 | 0.70 | GRIN2B (0.54) | GRIN2BPKMSMN1; SMN2P2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015454-A1 | METHOD OF INHIBITING SERINE PROTEASE ENZYMES | GLAXO GROUP LIMITED (GB) | 2000-07-05 | — | — | EP | disclosed |
| EP-0973775-A1 | PYROLOPYRROLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-01-26 | — | — | EP | disclosed |
| WO-1999012932-A1 | METHOD OF INHIBITING SERINE PROTEASE ENZYMES | GLAXO GROUP LIMITED (GB) | 1999-03-18 | — | — | WO | disclosed |
| WO-1998043975-A1 | PYROLOPYRROLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-10-08 | — | — | WO | disclosed |