Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409273 | 0.81 | MAPT (0.45) | MEN1KMT2AGRIN2BNPC1RAB9A | |
| SCHEMBL7409085 | 0.74 | MEN1 (0.44) | MEN1KMT2AGRIN2BNPC1RAB9A | |
| SCHEMBL7407393 | 0.70 | GRIN2B (0.42) | GRIN2BHSD17B10 | |
| SCHEMBL7511371 | 0.64 | NPC1 (0.43) | NPC1RAB9A | |
| SCHEMBL12540479 | 0.63 | MEN1 (1.00) | MEN1KMT2ATP53MDM2MAPT | |
| SCHEMBL3047836 | 0.63 | GRIN2B (0.54) | MEN1KMT2AGRIN2BNPC1RAB9A | |
| SCHEMBL21495082 | 0.61 | RAB9A (0.63) | MEN1KMT2ATP53NPC1RAB9A | |
| SCHEMBL10017802 | 0.61 | GRIN2B (0.48) | GRIN2BNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL5178153 | 0.61 | ME2 (0.61) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL6624123 | 0.61 | F2 (0.46) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973775-A1 | PYROLOPYRROLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998043975-A1 | PYROLOPYRROLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-10-08 | — | — | WO | disclosed |