SCHEMBL7407657

SCHEMBL7407657

O=C(O)CCC(=NO)c1ccc(-c2cnc(Cl)cn2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.38
NAPRT Q6XQN6 1/20 0.36
RAB9A P51151 4/20 0.35
SMN1; SMN2 Q16637 4/20 0.35
NPC1 O15118 4/20 0.35
FFAR1 O14842 2/20 0.35
LMNA P02545 1/20 0.35
CYP1A2 P05177 1/20 0.35
HIF1A Q16665 1/20 0.35
LDHA P00338 1/20 0.34
TP53 P04637 1/20 0.34
RXRA P19793 2/20 0.33
RXRB P28702 2/20 0.33
RXRG P48443 2/20 0.33
GAA P10253 1/20 0.33
KCNQ3 O43525 1/20 0.33
KCNQ2 O43526 1/20 0.33
NFKB1 P19838 1/20 0.32
NFKB2 Q00653 1/20 0.32
RELA Q04206 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7407653 1.00 HDAC8 (0.38) HDAC8NAPRTRAB9ASMN1; SMN2NPC1
SCHEMBL7411451 0.80 HDAC8 (0.43) HDAC8RAB9ASMN1; SMN2FFAR1LMNA
SCHEMBL7412483 0.80 HDAC4 (0.41) HDAC8RAB9ASMN1; SMN2NPC1FFAR1
SCHEMBL7412488 0.80 HDAC4 (0.41) HDAC8RAB9ASMN1; SMN2NPC1FFAR1
SCHEMBL7411447 0.80 HDAC8 (0.43) HDAC8RAB9ASMN1; SMN2FFAR1LMNA
SCHEMBL7406137 0.79 KMO (0.43) ALDH1A1
SCHEMBL7406138 0.79 KMO (0.43) ALDH1A1
SCHEMBL10021382 0.77 HDAC8 (0.48) HDAC8RAB9ASMN1; SMN2FFAR1LMNA
SCHEMBL4426383 0.77 HDAC8 (0.48) HDAC8RAB9ASMN1; SMN2FFAR1LMNA
SCHEMBL4426389 0.77 HDAC8 (0.48) HDAC8RAB9ASMN1; SMN2FFAR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6399612-B1 4-(4-(5-CHLORO-THIOPHEN-2-YL)-PHENYL)-4-OXO-BUTYRIC ACID; GELATINASE A (MMP-2), COLLAGENASE-3 (MMP-13), AND STROMELYSIN-1 (MMP-3) WARNER-LAMBERT COMPANY 2002-06-04 US claimed
WO-1999018079-A1 HETEROARYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES WARNER-LAMBERT COMPANY (US) 1999-04-15 WO claimed
US-6399612-B1 4-(4-(5-CHLORO-THIOPHEN-2-YL)-PHENYL)-4-OXO-BUTYRIC ACID; GELATINASE A (MMP-2), COLLAGENASE-3 (MMP-13), AND STROMELYSIN-1 (MMP-3) WARNER-LAMBERT COMPANY 2002-06-04 US disclosed
WO-1999018079-A1 HETEROARYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES WARNER-LAMBERT COMPANY (US) 1999-04-15 WO disclosed