Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 13/20 | 0.51 |
| ▸ | CTSG | P08311 | 1/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 6/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.43 |
| ▸ | FAP | Q12884 | 3/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.43 |
| ▸ | PREP | P48147 | 2/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.43 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7408179 | 1.00 | ELANE (0.51) | ELANECTSGXIAPDPP4DPP7 | |
| SCHEMBL31061570 | 0.89 | ELANE (0.62) | ELANECTSGXIAPDPP4DPP7 | |
| SCHEMBL7206990 | 0.88 | ELANE (0.48) | ELANECTSGXIAP | |
| SCHEMBL8428295 | 0.85 | ELANE (0.59) | ELANECTSGXIAPDPP4DPP7 | |
| SCHEMBL29641757 | 0.81 | XIAP (0.58) | ELANEXIAPDPP4DPP7FAP | |
| SCHEMBL6374299 | 0.80 | CMA1 (0.49) | ELANE | |
| SCHEMBL13668934 | 0.79 | XIAP (0.48) | ELANEXIAPDPP4DPP7FAP | |
| SCHEMBL2767860 | 0.79 | XIAP (0.48) | ELANEXIAPDPP4DPP7FAP | |
| SCHEMBL14982872 | 0.79 | ELANE (0.47) | ELANEXIAPDPP4DPP7FAP | |
| Bromide SCHEMBL3164359 | 0.78 | XIAP (0.47) | ELANEXIAPDPP4DPP7FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172044-B1 | ELASTASE INHIBITORS; ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS | AVENTIS PHARMACEUTICALS INC. | 2001-01-09 | — | — | US | disclosed |
| EP-0863915-B1 | ACYLATED ENOL DERIVATIVES OF ALPHA-KETOESTERS AND ALPHA-KETOAMIDES | HOECHST MARION ROUSSEL INC (US) | 2000-02-02 | — | — | EP | disclosed |
| US-5948886-A | ELASTASE INHIBITORS OR PRODRUGS; FOR TREATMENT OF EMPHYSEMA, CYSTIC FIBROSIS, ADULT RESPIRATORY DISTRESS SYNDROME, GOUT, DISSEMINATED INTRAVASCULAR COAGULATION, RHEUMATOID ARTHRITIS, CHRONIC BRONCHITIS, INFLAMMATORY BOWEL DISEASE, SEPTICEMIA | HOECHST MARION ROUSSEL, INC. (US) | 1999-09-07 | — | — | US | disclosed |
| EP-0863915-A1 | ACYLATED ENOL DERIVATIVES OF $g(a)-KETOESTERS AND $g(a)-KETOAMIDES | HOECHST MARION ROUSSEL, INC. (US) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997020856-A1 | ACYLATED ENOL DERIVATIVES OF α-KETOESTERS AND α-KETOAMIDES | HOECHST MARION ROUSSEL, INC. (US) | 1997-06-12 | — | — | WO | disclosed |