Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 17/20 | 0.43 |
| ▸ | MMP3 | P08254 | 13/20 | 0.43 |
| ▸ | MMP2 | P08253 | 13/20 | 0.43 |
| ▸ | MMP7 | P09237 | 12/20 | 0.43 |
| ▸ | MMP13 | P45452 | 12/20 | 0.43 |
| ▸ | MMP9 | P14780 | 7/20 | 0.43 |
| ▸ | MMP8 | P22894 | 6/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.43 |
| ▸ | MMP14 | P50281 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863639 | 0.86 | MMP1 (0.56) | MMP1MMP3MMP2MMP7MMP13 | |
| SCHEMBL6337141 | 0.84 | MMP1 (0.64) | MMP1MMP3MMP2MMP7MMP13 | |
| SCHEMBL7350096 | 0.83 | MMP1 (0.41) | MMP1MMP3MMP2MMP7MMP13 | |
| SCHEMBL6339420 | 0.78 | MMP1 (0.68) | MMP1MMP3MMP2MMP7MMP13 | |
| SCHEMBL6336327 | 0.77 | MMP1 (0.56) | MMP1MMP3MMP2MMP7MMP13 | |
| SCHEMBL7349146 | 0.77 | MMP1 (0.57) | MMP1MMP3MMP2MMP7MMP13 | |
| SCHEMBL7347544 | 0.77 | MMP1 (0.57) | MMP1MMP3MMP2MMP7MMP13 | |
| SCHEMBL7765223 | 0.75 | MMP1 (0.56) | MMP1MMP3MMP2MMP7MMP13 | |
| SCHEMBL7765228 | 0.75 | MMP1 (0.56) | MMP1MMP3MMP2MMP7MMP13 | |
| SCHEMBL6267902 | 0.75 | MMP1 (0.67) | MMP1MMP3MMP2MMP7MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874830-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES, AND METHODS AND INTERMEDIATES USEFUL FOR THEIR PREPARATION | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-04 | — | — | EP | disclosed |
| US-5753653-A | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses | AGOURON PHARMACEUTICALS, INC. (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1997020824-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES, AND METHODS AND INTERMEDIATES USEFUL FOR THEIR PREPARATION | AGOURON PHARMACEUTICALS, INC. (US) | 1997-06-12 | — | — | WO | disclosed |