Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 19/20 | 0.56 |
| ▸ | MMP3 | P08254 | 15/20 | 0.56 |
| ▸ | MMP2 | P08253 | 15/20 | 0.56 |
| ▸ | MMP13 | P45452 | 14/20 | 0.56 |
| ▸ | MMP7 | P09237 | 12/20 | 0.56 |
| ▸ | MMP9 | P14780 | 9/20 | 0.56 |
| ▸ | MMP14 | P50281 | 2/20 | 0.56 |
| ▸ | MMP8 | P22894 | 8/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6336327 | 0.91 | MMP1 (0.56) | MMP1MMP3MMP2MMP13MMP7 | |
| SCHEMBL6339420 | 0.90 | MMP1 (0.68) | MMP1MMP3MMP2MMP13MMP7 | |
| SCHEMBL6267902 | 0.89 | MMP1 (0.67) | MMP1MMP3MMP2MMP13MMP7 | |
| SCHEMBL6271303 | 0.88 | MMP1 (0.55) | MMP1MMP3MMP2MMP13MMP7 | |
| SCHEMBL7763224 | 0.88 | MMP1 (0.55) | MMP1MMP3MMP2MMP13MMP7 | |
| SCHEMBL7408195 | 0.86 | MMP1 (0.43) | MMP1MMP3MMP2MMP13MMP7 | |
| SCHEMBL6506286 | 0.82 | ADAM17 (0.70) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL6499220 | 0.82 | ADAM17 (0.70) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL6336108 | 0.80 | MMP1 (0.85) | MMP1MMP3MMP2MMP13MMP7 | |
| SCHEMBL6276978 | 0.79 | MMP1 (0.55) | MMP1MMP3MMP2MMP13MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095936-B1 | Intermediates useful for the preparation of metallproteinase inhibitors | AGOURON PHARMA (US) | 2004-11-24 | — | — | EP | disclosed |
| EP-1095936-A1 | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation | AGOURON PHARMACEUTICALS, INC. (US) | 2001-05-02 | — | — | EP | disclosed |