Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 6/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 5/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | YES1 | P07947 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | FGR | P09769 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | CSK | P41240 | 1/20 | 0.32 |
| ▸ | TEC | P42680 | 1/20 | 0.32 |
| ▸ | TXK | P42681 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740824 | 1.00 | CFD (0.36) | CFDDPP4CYP2D6HRH1BTK | |
| SCHEMBL742008 | 0.92 | CFD (0.35) | CFDDPP4CYP2D6HRH1BTK | |
| SCHEMBL742009 | 0.92 | CFD (0.35) | CFDDPP4CYP2D6HRH1BTK | |
| SCHEMBL740772 | 0.90 | HTT (0.39) | CFDDPP4CYP2D6HRH1BTK | |
| SCHEMBL740771 | 0.90 | HTT (0.39) | CFDDPP4CYP2D6HRH1BTK | |
| SCHEMBL741424 | 0.90 | CFD (0.36) | CFDDPP4CYP2D6HRH1BTK | |
| SCHEMBL741425 | 0.90 | CFD (0.36) | CFDDPP4CYP2D6HRH1BTK | |
| SCHEMBL741237 | 0.89 | KCNH2 (0.42) | CYP2D6HRH1KCNH2 | |
| SCHEMBL741236 | 0.89 | KCNH2 (0.42) | CYP2D6HRH1KCNH2 | |
| SCHEMBL741441 | 0.89 | CFD (0.36) | CFDDPP4CYP2D6HRH1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |