Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 5/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.34 |
| ▸ | DPP4 | P27487 | 5/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742008 | 1.00 | CFD (0.35) | CFDBTKHRH1CYP2D6DPP4 | |
| SCHEMBL741441 | 0.93 | CFD (0.36) | CFDBTKHRH1CYP2D6DPP4 | |
| SCHEMBL741440 | 0.93 | CFD (0.36) | CFDBTKHRH1CYP2D6DPP4 | |
| SCHEMBL741425 | 0.93 | CFD (0.36) | CFDBTKHRH1CYP2D6DPP4 | |
| SCHEMBL741424 | 0.93 | CFD (0.36) | CFDBTKHRH1CYP2D6DPP4 | |
| SCHEMBL740825 | 0.92 | CFD (0.36) | CFDBTKHRH1CYP2D6DPP4 | |
| SCHEMBL740824 | 0.92 | CFD (0.36) | CFDBTKHRH1CYP2D6DPP4 | |
| SCHEMBL740772 | 0.91 | HTT (0.39) | CFDBTKHRH1CYP2D6DPP4 | |
| SCHEMBL740771 | 0.91 | HTT (0.39) | CFDBTKHRH1CYP2D6DPP4 | |
| SCHEMBL742549 | 0.88 | MCHR1 (0.35) | CFDBTKHRH1CYP2D6DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |