Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.67 |
| ▸ | DRD2 | P14416 | 5/20 | 0.59 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.58 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17842060 | 0.86 | LTA4H (0.80) | LTA4HTMEM97SIGMAR1HTR1AHTR7 | |
| SCHEMBL6681568 | 0.84 | LTA4H (0.71) | LTA4HDRD2CACNA1GTMEM97SIGMAR1 | |
| SCHEMBL17858461 | 0.84 | DRD2 (0.77) | LTA4HDRD2CACNA1G | |
| SCHEMBL7135163 | 0.84 | LTA4H (0.81) | LTA4HDRD2CACNA1GKDM4E | |
| SCHEMBL17858507 | 0.83 | LTA4H (0.64) | LTA4HDRD2TMEM97SIGMAR1HTR1A | |
| SCHEMBL17858409 | 0.83 | LTA4H (0.64) | LTA4HCACNA1GTMEM97SIGMAR1HTR1A | |
| SCHEMBL14204982 | 0.83 | LTA4H (0.81) | LTA4HTMEM97SIGMAR1KCNA5KDM4E | |
| SCHEMBL7253842 | 0.82 | HTR2A (0.64) | LTA4HTMEM97SIGMAR1KCNA5KDM4E | |
| SCHEMBL7137454 | 0.81 | LTA4H (0.77) | LTA4HTMEM97SIGMAR1KCNA5KDM4E | |
| SCHEMBL7141718 | 0.80 | LTA4H (1.00) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054858-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED-ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999042436-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED-ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1999-08-26 | — | — | WO | disclosed |