Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL277729 | 0.91 | ALOX15 (0.40) | MMP3ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL276894 | 0.77 | ALDH1A1 (0.40) | ALDH1A1HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL9687506 | 0.74 | ALDH1A1 (0.41) | BCL2L1BACE1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL9934488 | 0.69 | ALOX15 (0.40) | ALDH1A1HPGDKDM4EGAAMAPT | |
| SCHEMBL31609391 | 0.67 | ALOX15 (0.43) | ALDH1A1HPGDKDM4EMEN1GAA | |
| Biphenyl SCHEMBL7413481 | 0.66 | ALOX15 (0.79) | BCL2L1MMP3ALDH1A1HPGDHSD17B10 | |
| Biphenyl SCHEMBL28042419 | 0.66 | ALDH1A1 (0.71) | BCL2L1MMP3ALOX5BACE1ALDH1A1 | |
| Biphenyl SCHEMBL28098924 | 0.65 | ALDH1A1 (0.90) | BCL2L1MMP3ALOX5BACE1ALDH1A1 | |
| SCHEMBL16915952 | 0.64 | ALOX15 (0.40) | ALDH1A1HPGDHSD17B10KDM4EGAA | |
| SCHEMBL5356727 | 0.64 | ALOX15 (0.40) | ALDH1A1HPGDKDM4EGAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674879-A | Compositions including and methods of using conformationally restricted angiotensin II antagonist | G.D. SEARLE & CO. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5426105-A | Cardiovascular disorders | G.D. SEARLE & CO. (US) | 1995-06-20 | — | — | US | disclosed |