SCHEMBL7409166

SCHEMBL7409166

OCC(Cl)(Cl)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.50
CYP1A2 P05177 2/20 0.46
CYP2C19 P33261 2/20 0.39
CYP2C9 P11712 1/20 0.39
ALDH1A1 P00352 3/20 0.38
KCNN4 O15554 2/20 0.38
HIF1A Q16665 1/20 0.37
TAAR1 Q96RJ0 1/20 0.36
ALOX15 P16050 1/20 0.36
KDM4E B2RXH2 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
ESR1 P03372 2/20 0.34
ESR2 Q92731 2/20 0.34
PTPN1 P18031 1/20 0.34
CYP3A4 P08684 1/20 0.34
CNR1 P21554 1/20 0.34
CNR2 P34972 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8375768 0.80 TSHR (0.46) TSHRCYP1A2CYP2C19CYP2C9ALDH1A1
SCHEMBL11237111 0.79 TSHR (0.50) TSHRCYP1A2CYP2C19CYP2C9ALDH1A1
SCHEMBL7476372 0.77 TSHR (0.48) TSHRCYP1A2CYP2C19CYP2C9ALDH1A1
SCHEMBL8376477 0.77 TSHR (0.42) TSHRCYP1A2CYP2C19CYP2C9TDP1
SCHEMBL1829396 0.76 TSHR (0.52) TSHRCYP1A2CYP2C19CYP2C9ALDH1A1
SCHEMBL15228184 0.75 TSHR (0.46) TSHRCYP1A2CYP2C19CYP2C9ALDH1A1
Hydrochloric Acid SCHEMBL11308929 0.75 TSHR (0.46) TSHRCYP1A2CYP2C19CYP2C9ALDH1A1
SCHEMBL10546410 0.75 TSHR (0.46) TSHRCYP1A2CYP2C19CYP2C9ALDH1A1
SCHEMBL9229930 0.75 TSHR (0.44) TSHRCYP2C19CYP2C9ALDH1A1TDP1
SCHEMBL6685341 0.74 TSHR (0.50) TSHRCYP1A2CYP2C19ALDH1A1KCNN4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105087662-A Method for producing chiral chlorphenyl chlorethanol by use of yeast UNIV QINGDAO SCIENCE & TECHNOLOGY 2015-11-25 CN disclosed
CN-105063103-A Method for producing chiral phenyl dichloroethanol with molds UNIV QINGDAO SCIENCE & TECHNOLOGY 2015-11-18 CN disclosed
US-6005116-A HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA SANKYO COMPANY, LIMITED (JP) 1999-12-21 US disclosed
EP-0885891-A1 ISOXAZOLE DERIVATIVES SANKYO COMPANY LIMITED (JP) 1998-12-23 EP disclosed
US-5244884-A Tripeptide THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1993-09-14 US disclosed
EP-0226641-B1 OXODIAZINE COMPOUNDS YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1989-10-18 EP disclosed
US-4713381-A ANTICOAGULANTS, ANALGESICS, ANTIINFLAMMATORY AGENT YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1987-12-15 US disclosed
EP-0226641-A1 OXODIAZINE COMPOUNDS. YOSHITOMI PHARMACEUTICAL (JP) 1987-07-01 EP disclosed
WO-1986007059-A2 OXODIAZINE COMPOUNDS YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1986-12-04 WO disclosed
US-4064239-A LIVER FLUKES MERCK & CO., INC. (US) 1977-12-20 US disclosed
US-3966900-A INSECTICIDES AIRWICK INDUSTRIES, INC. (US) 1976-06-29 US disclosed