SCHEMBL7409169

SCHEMBL7409169

CC(=O)Oc1cnc(F)c(C)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLA P06280 4/20 0.46
ALDH1A1 P00352 3/20 0.46
HPGD P15428 2/20 0.46
F2 P00734 1/20 0.46
LMNA P02545 3/20 0.41
ACHE P22303 3/20 0.40
CYP4F2 P78329 1/20 0.40
CYP4A11 Q02928 1/20 0.40
CYP3A4 P08684 2/20 0.37
KDM4E B2RXH2 5/20 0.36
GAA P10253 3/20 0.36
KMT2A Q03164 2/20 0.36
HSD17B10 Q99714 2/20 0.35
PTPRB P23467 1/20 0.35
MAPT P10636 3/20 0.35
TSHR P16473 1/20 0.35
CASP1 P29466 1/20 0.35
CASP7 P55210 1/20 0.35
POLB P06746 1/20 0.34
PKM P14618 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28723881 0.84 KMT2A (0.40) GLAALDH1A1HPGDF2KMT2A
SCHEMBL11513704 0.81 GLA (0.49) GLAALDH1A1HPGDF2LMNA
SCHEMBL27459526 0.81 ELANE (0.43) KMT2AMAPTMEN1ELANE
SCHEMBL7405787 0.81 ALDH1A1 (0.45) GLAALDH1A1HPGDF2LMNA
SCHEMBL11447584 0.80 GLA (0.47) GLAALDH1A1HPGDF2LMNA
SCHEMBL27832795 0.79 ALDH1A1 (0.44) GLAALDH1A1HPGDF2LMNA
SCHEMBL6583226 0.79 GLA (0.46) GLAALDH1A1HPGDF2LMNA
SCHEMBL6584035 0.78 ALDH1A1 (0.47) GLAALDH1A1HPGDF2LMNA
SCHEMBL23829833 0.76 MCL1 (0.33) ALDH1A1KDM4EKMT2AMAPTPOLB
SCHEMBL19088190 0.75 ALDH1A1 (0.36) ALDH1A1CYP3A4KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0950057-B1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS ABBOTT LAB (US) 2002-11-13 EP disclosed
US-6403575-B1 ANTI-INFLAMMATORIES ABBOTT LABORATORIES 2002-06-11 US disclosed
EP-0846114-B1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2001-12-05 EP disclosed
EP-1047690-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-11-02 EP disclosed
US-6133253-A NEURONAL CELL DEATH PREVENTORS AND ANTI-INFLAMMATORIES ABBOTT LABORATORIES (US) 2000-10-17 US disclosed
EP-0950057-A1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS Abbott Laboratories (US) 1999-10-20 EP disclosed
WO-1999032480-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1999-07-01 WO disclosed
WO-1998025920-A1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS ABBOTT LABORATORIES (US) 1998-06-18 WO disclosed
EP-0846114-A1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1998-06-10 EP disclosed
WO-1996040682-A1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1996-12-19 WO disclosed