SCHEMBL6584035

SCHEMBL6584035

C=Cc1cc(OC(C)=O)cnc1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.47
F2 P00734 1/20 0.47
GLA P06280 1/20 0.47
HPGD P15428 1/20 0.47
CYP4F2 P78329 1/20 0.37
CYP4A11 Q02928 1/20 0.37
LMNA P02545 3/20 0.35
MAPT P10636 3/20 0.35
CYP3A4 P08684 2/20 0.35
KDM4E B2RXH2 2/20 0.35
MEN1 O00255 1/20 0.35
TTR P02766 1/20 0.35
TP53 P04637 1/20 0.35
KMT2A Q03164 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
ACHE P22303 3/20 0.34
CYP19A1 P11511 1/20 0.33
PTPN1 P18031 1/20 0.32
POLB P06746 1/20 0.32
PKM P14618 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7409169 0.78 GLA (0.46) ALDH1A1F2GLAHPGDCYP4F2
SCHEMBL7405787 0.77 ALDH1A1 (0.45) ALDH1A1F2GLAHPGDCYP4F2
SCHEMBL18318758 0.73 LMNA (0.47) ALDH1A1F2GLAHPGDLMNA
SCHEMBL17748187 0.72 ACHE (0.45) ALDH1A1F2GLAHPGDLMNA
SCHEMBL6582447 0.70 ESR2 (0.37)
SCHEMBL21988953 0.69 ALDH1A1 (0.71) ALDH1A1F2GLAHPGDCYP4F2
SCHEMBL21240945 0.68 NNMT (0.37) ALDH1A1F2GLAHPGDLMNA
SCHEMBL11011775 0.68 PTGS1 (0.36) ALDH1A1F2GLAHPGDLMNA
SCHEMBL11513704 0.67 GLA (0.49) ALDH1A1F2GLAHPGDCYP4F2
SCHEMBL7407630 0.67 ALDH1A1 (0.49) ALDH1A1F2GLAHPGDLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934308-B1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2004-08-11 EP disclosed
EP-0950057-B1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS ABBOTT LAB (US) 2002-11-13 EP disclosed
US-6437138-B1 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS ABBOTT LABORATORIES 2002-08-20 US disclosed
US-6403575-B1 ANTI-INFLAMMATORIES ABBOTT LABORATORIES 2002-06-11 US disclosed
US-6133253-A NEURONAL CELL DEATH PREVENTORS AND ANTI-INFLAMMATORIES ABBOTT LABORATORIES (US) 2000-10-17 US disclosed
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US disclosed
EP-0950057-A1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS Abbott Laboratories (US) 1999-10-20 EP disclosed
EP-0934308-A1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1999-08-11 EP disclosed
WO-1998025920-A1 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS ABBOTT LABORATORIES (US) 1998-06-18 WO disclosed
WO-1997046554-A1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1997-12-11 WO disclosed