Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.84 |
| ▸ | F10 | P00742 | 3/20 | 0.68 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410644 | 1.00 | MEN1 (0.84) | MEN1KMT2AF10NPC1MAPT | |
| SCHEMBL7407190 | 0.90 | F10 (0.68) | MEN1KMT2AF10NPC1MAPT | |
| SCHEMBL7404902 | 0.90 | F10 (0.68) | MEN1KMT2AF10NPC1MAPT | |
| SCHEMBL7402259 | 0.89 | MEN1 (0.67) | MEN1KMT2AF10NPC1MAPT | |
| SCHEMBL7411341 | 0.88 | MEN1 (0.65) | MEN1KMT2AF10MAPTALDH1A1 | |
| SCHEMBL7413404 | 0.87 | KMT2A (0.64) | MEN1KMT2AF10NPC1MAPT | |
| SCHEMBL8417461 | 0.87 | KMT2A (0.64) | MEN1KMT2AF10NPC1MAPT | |
| SCHEMBL7407418 | 0.86 | F10 (0.79) | MEN1KMT2AF10NPC1ALDH1A1 | |
| SCHEMBL7411939 | 0.85 | MEN1 (0.60) | MEN1KMT2AF10MAPTGAA | |
| SCHEMBL5221185 | 0.84 | MEN1 (0.84) | MEN1KMT2AF10NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999042439-A1 | NOVEL THIOBENZAMIDES | ROCHE DIAGNOSTICS GMBH (DE) | 1999-08-26 | — | — | WO | claimed |
| WO-1999042439-A1 | NOVEL THIOBENZAMIDES | ROCHE DIAGNOSTICS GMBH (DE) | 1999-08-26 | — | — | WO | disclosed |
| EP-0937711-A1 | Thiobenzamides, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1999-08-25 | — | — | EP | disclosed |