Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502160 | 0.90 | ALDH1A1 (0.49) | HSD11B1ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL1328541 | 0.87 | ALDH1A1 (0.51) | HSD11B1ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL3093813 | 0.86 | SMN1; SMN2 (0.70) | HSD11B1ALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL14606834 | 0.86 | HSD11B1 (0.59) | HSD11B1ALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL30680404 | 0.86 | SMN1; SMN2 (0.54) | HSD11B1ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL10827952 | 0.86 | SMN1; SMN2 (0.54) | HSD11B1ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL31544569 | 0.84 | HSD11B1 (0.57) | HSD11B1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14580275 | 0.84 | HSD11B1 (0.57) | HSD11B1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1327237 | 0.78 | KMT2A (0.56) | ALDH1A1KDM4EHPGDNPC1RAB9A | |
| SCHEMBL15669005 | 0.77 | SMN1; SMN2 (0.67) | HSD11B1ALDH1A1SMN1; SMN2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502543-A | Targeted protein compounds, pharmaceutical compositions and therapeutic applications thereof | 拜欧斯瑞克斯公司 | 2022-05-13 | — | — | CN | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | HSD11B1 1658/4885ALDH1A1 2036/4885SMN1; SMN2 1477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.