Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.83 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | RB1 | P06400 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1445173 | 0.91 | SIGMAR1 (1.00) | SIGMAR1HTR6MCHR1HTR2AKCNH2 | |
| SCHEMBL2814660 | 0.80 | SIGMAR1 (0.60) | SIGMAR1HTR6RB1MCHR1 | |
| SCHEMBL7415387 | 0.80 | SIGMAR1 (0.85) | SIGMAR1HTR6 | |
| SCHEMBL2815101 | 0.74 | SIGMAR1 (0.56) | SIGMAR1HTR6MCHR1 | |
| SCHEMBL15869674 | 0.72 | SIGMAR1 (0.45) | SIGMAR1HTR6MCHR1 | |
| SCHEMBL15869675 | 0.72 | SIGMAR1 (0.45) | SIGMAR1HTR6MCHR1 | |
| SCHEMBL15869717 | 0.72 | SIGMAR1 (0.45) | SIGMAR1HTR6MCHR1 | |
| SCHEMBL7406069 | 0.71 | SIGMAR1 (1.00) | SIGMAR1HTR6MCHR1 | |
| SCHEMBL2814203 | 0.71 | SIGMAR1 (0.71) | SIGMAR1HTR6RB1MCHR1 | |
| Hydrochloric Acid SCHEMBL23828310 | 0.70 | SIGMAR1 (0.69) | SIGMAR1HTR6RB1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274307-B1 | BRIDGED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES INC (US) | 2015-07-29 | — | — | EP | disclosed |
| US-5250537-A | Treating psychoses | SCIOS NOVA INC. (US) | 1993-10-05 | — | — | US | disclosed |
| US-5250537-A | Treating psychoses | SCIOS NOVA INC. (US) | 1993-10-05 | — | — | US | disclosed |