Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15869675 | 1.00 | SIGMAR1 (0.45) | SIGMAR1MCHR1HTR6PIK3CGADORA3 | |
| SCHEMBL15869674 | 1.00 | SIGMAR1 (0.45) | SIGMAR1MCHR1HTR6PIK3CGADORA3 | |
| SCHEMBL15869716 | 0.77 | SIGMAR1 (0.50) | SIGMAR1PIK3CGADORA3HTR1ASLC6A2 | |
| SCHEMBL15869659 | 0.77 | SIGMAR1 (0.50) | SIGMAR1PIK3CGADORA3HTR1ASLC6A2 | |
| SCHEMBL15869658 | 0.77 | SIGMAR1 (0.50) | SIGMAR1PIK3CGADORA3HTR1ASLC6A2 | |
| SCHEMBL15869581 | 0.73 | SIGMAR1 (0.57) | SIGMAR1MCHR1ADORA3 | |
| SCHEMBL15869580 | 0.73 | SIGMAR1 (0.57) | SIGMAR1MCHR1ADORA3 | |
| SCHEMBL15869644 | 0.73 | SIGMAR1 (0.57) | SIGMAR1MCHR1ADORA3 | |
| SCHEMBL7409377 | 0.72 | SIGMAR1 (0.83) | SIGMAR1MCHR1HTR6 | |
| SCHEMBL11347383 | 0.67 | CHRM2 (0.43) | HTR6PIK3CGADORA3HTR1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778959-B2 | AZA-bridged ring-fused indoles and indolines | ABBVIE INC. (US) | 2014-07-15 | — | — | US | claimed |
| US-8778959-B2 | AZA-bridged ring-fused indoles and indolines | ABBVIE INC. (US) | 2014-07-15 | — | — | US | disclosed |