Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 4/20 | 0.43 |
| ▸ | MMP1 | P03956 | 3/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NPR3 | P17342 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409388 | 1.00 | MMP3 (0.43) | MMP3MMP1MMP7FPR2MEN1 | |
| SCHEMBL7606096 | 0.92 | MMP1 (0.53) | MMP3MMP1MMP7FPR2MEN1 | |
| SCHEMBL7606100 | 0.92 | MMP1 (0.53) | MMP3MMP1MMP7FPR2MEN1 | |
| SCHEMBL7402056 | 0.85 | MMP3 (0.42) | MMP3MMP1MMP7FPR2KMT2A | |
| SCHEMBL7402055 | 0.85 | MMP3 (0.42) | MMP3MMP1MMP7FPR2KMT2A | |
| SCHEMBL7605453 | 0.82 | MMP3 (0.56) | MMP3MMP1MMP7MEN1KMT2A | |
| SCHEMBL7605447 | 0.82 | MMP3 (0.56) | MMP3MMP1MMP7MEN1KMT2A | |
| SCHEMBL7764954 | 0.82 | MMP3 (0.56) | MMP3MMP1MMP7MEN1KMT2A | |
| SCHEMBL7403920 | 0.77 | MMP1 (0.52) | MMP3MMP1MMP7FPR2AAK1 | |
| SCHEMBL7403919 | 0.77 | MMP1 (0.52) | MMP3MMP1MMP7FPR2AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937042-A1 | HETEROARYL SUCCINAMIDES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998017643-A1 | HETEROARYL SUCCINAMIDES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1998-04-30 | — | — | WO | disclosed |