Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9239118 | 0.94 | SIGMAR1 (0.89) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL10357012 | 0.91 | SIGMAR1 (0.84) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL6681882 | 0.90 | SIGMAR1 (0.82) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL10357938 | 0.86 | SIGMAR1 (0.76) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL8642037 | 0.86 | LMNA (0.78) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL8647649 | 0.86 | LMNA (0.83) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL16581967 | 0.85 | SIGMAR1 (0.74) | SIGMAR1 | |
| SCHEMBL6255520 | 0.84 | SIGMAR1 (1.00) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL8645362 | 0.84 | LMNA (0.81) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA | |
| SCHEMBL10551886 | 0.84 | SIGMAR1 (0.73) | SIGMAR1SLC6A4SLC6A3SLC6A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6387389-B1 | Sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines and their use | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2002-05-14 | — | — | US | disclosed |
| EP-0620814-B1 | NOVEL PIPRAZINE CARBOXAMIDES | PHARMACIA & UPJOHN AB (SE) | 2000-03-22 | — | — | EP | disclosed |
| EP-0937053-A1 | SUSTAINED-RELEASE DERIVATIVES OF HYDROXYLATED ANALOGS OF SUBSTITUTED 1- 2 BIS(ARYL)METHOXY]ETHYL]-PIPERAZINES AND -HOMOPIPERAZINES AND THEIR USE AS NONCOMPETITIVE ANTAGONISTS OF DOPAMINE REUPTAKE | THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998018769-A1 | SUSTAINED-RELEASE DERIVATIVES OF HYDROXYLATED ANALOGS OF SUBSTITUTED 1-[2[BIS(ARYL)METHOXY]ETHYL]-PIPERAZINES AND -HOMOPIPERAZINES AND THEIR USE AS NONCOMPETITIVE ANTAGONISTS OF DOPAMINE REUPTAKE | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-05-07 | — | — | WO | disclosed |
| EP-0541617-B1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK AS (DK) | 1997-06-04 | — | — | EP | disclosed |
| US-5574031-A | Piperazine carboxamides | PHARMACIA AKTIEBOLAG (SE) | 1996-11-12 | — | — | US | disclosed |
| EP-0686635-A1 | Pyridylthiazolidinecarboxylic acid amide derivatives, their preparation and their therapeutic uses | Sankyo Company Limited (JP) | 1995-12-13 | — | — | EP | disclosed |
| US-5470851-A | Antihistamine, anticoagulants | SANKYO COMPANY, LIMITED (JP) | 1995-11-28 | — | — | US | disclosed |
| US-5371233-A | 2-(tetrazol-5-yl)-1,1'-biphenyl derivatives, their preparation and their use as synthetic intermediates | SYNTHELABO (FR) | 1994-12-06 | — | — | US | disclosed |
| EP-0620814-A1 | NOVEL PIPRAZINE CARBOXAMIDES | Pharmacia & Upjohn Aktiebolag (SE) | 1994-10-26 | — | — | EP | disclosed |
| WO-1992001679-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1992-02-06 | — | — | WO | disclosed |
| EP-0436734-A1 | NEW AMINOPIPERAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-17 | — | — | EP | disclosed |
| US-4874765-A | 1,4-Disubstituted piperazines having dopaminergic activity | RICHTER GEDEON VEGYESZETI GYAR (HU) | 1989-10-17 | — | — | US | disclosed |
| EP-0099148-B1 | PIPERAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | GIST-BROCADES N.V. (NL) | 1988-02-17 | — | — | EP | disclosed |
| EP-0243903-A1 | Optionally substituted 1-(omega[bis(phenyl)-alcoxy]-alkyl)-4-(alkenyl)piperazines and -4-(alkynyl)piperazines, process for their preparation and medicines containing them | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1987-11-04 | — | — | EP | disclosed |
| US-4476129-A | DOPAMINERGIC AND ANTICMOLINERGIC AGENTS | GIST-BROCADES N.V. (NL) | 1984-10-09 | — | — | US | disclosed |
| EP-0099148-A1 | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them | GIST-BROCADES N.V. (NL) | 1984-01-25 | — | — | EP | disclosed |
| US-4265894-A | TREATING PARKINSON'S DISEASE AND ACROMEGALY | GIST BROCADES, N.V. (NL) | 1981-05-05 | — | — | US | disclosed |
| US-4202896-A | DOPAMINERGIC ACTIVITY | GIST-BROCADES N.V. (NL) | 1980-05-13 | — | — | US | disclosed |
| US-4096259-A | PSCHOLOGICAL DISORDERS | BUZAS ANDRE | 1978-06-20 | — | — | US | disclosed |