Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 13/20 | 0.50 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 4/20 | 0.37 |
| ▸ | PIM1 | P11309 | 4/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | CIT | O14578 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.35 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.35 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.34 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415905 | 0.81 | PARP1 (0.50) | PARP1PARP2 | |
| SCHEMBL7415820 | 0.75 | PARP1 (0.56) | PARP1SCN10ACDC7PIM1CSNK2B | |
| SCHEMBL6869338 | 0.69 | PARP1 (0.69) | PARP1PIM1PARP2DYRK1A | |
| SCHEMBL7702651 | 0.67 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL630259 | 0.67 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL633643 | 0.67 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL1298158 | 0.67 | PARP1 (0.80) | PARP1PIM1PARP2DYRK1A | |
| SCHEMBL15844095 | 0.67 | PARP1 (0.53) | PARP1SCN10ACDC7PIM1CSNK2B | |
| SCHEMBL15844096 | 0.67 | PARP1 (0.53) | PARP1SCN10ACDC7PIM1CSNK2B | |
| SCHEMBL18596118 | 0.66 | SCN10A (0.55) | PARP1SCN10ACDC7PIM1CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |