Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741001 | 1.00 | CHRM1 (0.49) | CHRM1HRH1PRPS1HTR2AHTR2C | |
| SCHEMBL740755 | 0.88 | HRH1 (0.52) | CHRM1HRH1BRD4RENKCNH2 | |
| SCHEMBL740756 | 0.88 | HRH1 (0.52) | CHRM1HRH1BRD4RENKCNH2 | |
| SCHEMBL741972 | 0.84 | HRH1 (0.53) | CHRM1HRH1BRD4RENJAK2 | |
| SCHEMBL741971 | 0.84 | HRH1 (0.53) | CHRM1HRH1BRD4RENJAK2 | |
| SCHEMBL737976 | 0.84 | HRH1 (0.55) | CHRM1HRH1BRD4RENKCNH2 | |
| SCHEMBL742774 | 0.84 | HRH1 (0.54) | CHRM1HRH1BRD4RENKCNH2 | |
| SCHEMBL740741 | 0.84 | HRH1 (0.54) | CHRM1HRH1PRPS1BRD4REN | |
| SCHEMBL742773 | 0.84 | HRH1 (0.54) | CHRM1HRH1BRD4RENKCNH2 | |
| SCHEMBL737977 | 0.84 | HRH1 (0.55) | CHRM1HRH1BRD4RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |