Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 19/20 | 0.65 |
| ▸ | ITGB3 | P05106 | 16/20 | 0.65 |
| ▸ | ITGB6 | P18564 | 6/20 | 0.53 |
| ▸ | ITGB5 | P18084 | 5/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | ITGB8 | P26012 | 3/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376995 | 0.86 | ITGB3 (0.86) | ITGAVITGB3ITGB6ITGB5ITGA2B | |
| SCHEMBL22029454 | 0.81 | ITGAV (0.75) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL21328993 | 0.81 | ITGAV (0.71) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL29416577 | 0.81 | ITGAV (0.71) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL7980834 | 0.81 | ITGB3 (0.77) | ITGAVITGB3ITGB6ITGB5ITGA2B | |
| SCHEMBL10051022 | 0.80 | ITGAV (0.71) | ITGAVITGB3ITGB6ITGB5ITGA2B | |
| SCHEMBL21330221 | 0.79 | ITGAV (0.68) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL29416370 | 0.79 | ITGAV (0.68) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL6798154 | 0.79 | ITGAV (0.58) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL3219843 | 0.79 | ITGAV (0.65) | ITGAVITGB3ITGB6ITGB5ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880511-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1999-06-16 | — | — | EP | claimed |
| EP-0880511-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-12-02 | — | — | EP | claimed |
| WO-1997026250-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-07-24 | — | — | WO | claimed |
| US-6294549-B1 | COMPOUNDS USEFUL FOR INHIBITING RESTENOSIS, ANGIOGENESIS, ATHEROSCLEROSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, INFLAMMATION OR TUMOR GROWTH. | MERCK & CO., INC. | 2001-09-25 | — | — | US | disclosed |
| US-5952306-A | INHIBITING THE BINDING OF FIBRINOGEN TO BLOOD PLATELETS AND INHIBITING THE AGGREGATION OF BLOOD PLATELETS; INHIBITING OSTEOCLAST CELLULAR ADHESION TO BONE SURFACES | MERCK & CO., INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0880511-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1999-06-16 | — | — | EP | disclosed |
| EP-0880511-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997026250-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-07-24 | — | — | WO | disclosed |