Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HTR2B | P41595 | 8/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741004 | 1.00 | POLB (0.54) | POLBKDM4EHTR2BUSP30MAPK1 | |
| SCHEMBL738960 | 0.83 | HTR2B (0.53) | POLBKDM4EHTR2BUSP30 | |
| SCHEMBL2514536 | 0.83 | HTR2B (0.61) | POLBKDM4EHTR2BUSP30MAPK1 | |
| SCHEMBL2520100 | 0.83 | HTR2B (0.61) | POLBKDM4EHTR2BUSP30MAPK1 | |
| SCHEMBL742415 | 0.83 | HTR2B (0.61) | POLBKDM4EHTR2BUSP30MAPK1 | |
| SCHEMBL741139 | 0.82 | POLB (0.61) | POLBKDM4EHTR2BUSP30MAPK1 | |
| SCHEMBL739141 | 0.80 | HTR2B (0.71) | POLBKDM4EHTR2B | |
| SCHEMBL741695 | 0.80 | POLB (0.53) | POLBKDM4EHTR2BUSP30MAPK1 | |
| SCHEMBL13853671 | 0.79 | POLB (0.62) | POLBKDM4EHTR2BUSP30MAPK1 | |
| SCHEMBL740315 | 0.79 | POLB (0.50) | POLBKDM4EHTR2BUSP30MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |