SCHEMBL7410062

SCHEMBL7410062

CCCCOc1nsc(Cl)n1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
HSD17B10 Q99714 1/20 0.37
CYP2D6 P10635 7/20 0.36
CYP1A2 P05177 6/20 0.36
CYP3A4 P08684 5/20 0.36
CYP19A1 P11511 5/20 0.34
CYP2C9 P11712 5/20 0.34
CYP2C19 P33261 5/20 0.34
GLA P06280 1/20 0.33
CHRM1 P11229 1/20 0.33
CA12 O43570 2/20 0.32
CA1 P00915 2/20 0.32
CA2 P00918 2/20 0.32
CA9 Q16790 2/20 0.32
CA3 P07451 1/20 0.32
CA4 P22748 1/20 0.32
CA6 P23280 1/20 0.32
CA7 P43166 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL598441 0.73 CYP2D6 (0.43) SMN1; SMN2NPC1RAB9AHSD17B10CYP2D6
SCHEMBL1318906 0.72 RAB9A (0.41) SMN1; SMN2NPC1RAB9AHSD17B10CYP2D6
SCHEMBL6051629 0.72 RAB9A (0.41) SMN1; SMN2NPC1RAB9AHSD17B10CYP2D6
SCHEMBL17585443 0.69 PDE10A (0.43) SMN1; SMN2NPC1RAB9AHSD17B10CYP2D6
Hydrochloric Acid SCHEMBL7403583 0.69 L3MBTL1 (0.36) SMN1; SMN2NPC1RAB9ACYP1A2CYP2C19
SCHEMBL13827717 0.68 NPC1 (0.58) SMN1; SMN2NPC1RAB9AHSD17B10CYP2D6
SCHEMBL14376402 0.68 SMN1; SMN2 (0.39) SMN1; SMN2NPC1RAB9ALMNAMAPK1
SCHEMBL14698919 0.67 MEN1 (0.33) KMT2A
SCHEMBL5381295 0.67 SOAT1 (0.37) SMN1; SMN2NPC1RAB9AHSD17B10KMT2A
SCHEMBL16986068 0.67 GAK (0.37) SMN1; SMN2NPC1RAB9AHSD17B10CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6468977-B1 COMPOUNDS USEFUL IN TREATMENT TREATMENT OF DISORDER AND/OR DISEASE CAUSED BY ACTIVITY OF ENZYMES SUCH AS HUMAN RHINOVIRUS 3C PROTEASE, TRANSGLUTAMINASE AND CATHEPSINS APOTEX INC. (CA) 2002-10-22 US disclosed
WO-2001090095-A1 THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES APOTEX INC. (CA) 2001-11-29 WO disclosed
CN-1291993-A Thiadiazole compounds useful as cysteine activity dependent enzyme inhibitors APOTEX INC (CA) 2001-04-18 CN disclosed
US-6162791-A Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes APOTEX INC. (CA) 2000-12-19 US disclosed
EP-1058690-A1 THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES APOTEX INC. (CA) 2000-12-13 EP disclosed
US-6060472-A Thiadiazole compounds useful as inhibitors of H+ /K+ atpase APOTEX INC. (CA) 2000-05-09 US disclosed
WO-1999051584-A1 THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF H+/K+ ATPASE APOTEX INC. (CA) 1999-10-14 WO disclosed
WO-1999045027-A1 THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES APOTEX INC. (CA) 1999-09-10 WO disclosed