Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.64 |
| ▸ | PDE2A | O00408 | 3/20 | 0.64 |
| ▸ | PDE1A | P54750 | 2/20 | 0.64 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.64 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.64 |
| ▸ | ADH5 | P11766 | 9/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409627 | 0.83 | PDE3B (0.69) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10762139 | 0.83 | PDE3B (0.72) | PDE3BPDE3APDE2APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL10761419 | 0.82 | PDE3B (0.71) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10762619 | 0.81 | PDE3B (0.43) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7411008 | 0.81 | PDE3B (0.69) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10704473 | 0.80 | CCNC (0.67) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10763661 | 0.79 | PDE3B (0.41) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7411067 | 0.78 | PDE3A (1.00) | PDE3BPDE3APDE2APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL7406382 | 0.77 | PDE3A (0.98) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL3204344 | 0.77 | ADH5 (0.52) | PDE3BPDE3APDE2AADH5PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0102227-B1 | 2(1H)-PYRIDINONES, USEFUL AS CARDIOTONIC AGENTS, AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1989-05-03 | — | — | EP | disclosed |
| US-4607037-A | Cardiotonic 2(1H)-pyridinones | WARNER-LAMBERT COMPANY (US) | 1986-08-19 | — | — | US | disclosed |
| US-4503061-A | Substituted phenyl-pyridinones as cardiotonic agents | WARNER-LAMBERT COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0102227-A2 | 2(1H)-pyridinones, useful as cardiotonic agents, and their production | WARNER-LAMBERT COMPANY (US) | 1984-03-07 | — | — | EP | disclosed |