Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | DDX3X | O00571 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29776993 | 0.86 | LMNA (0.72) | HTTPKMKMT2ALMNAMAPT | |
| SCHEMBL12305610 | 0.86 | LMNA (0.72) | HTTPKMKMT2ALMNAMAPT | |
| SCHEMBL3462263 | 0.86 | KMT2A (0.81) | HTTPKMKMT2ALMNAMAPT | |
| SCHEMBL17978450 | 0.83 | HTT (0.60) | HTTPKMKMT2ALMNAMAPT | |
| SCHEMBL5594951 | 0.83 | HTT (0.71) | HTTPKMKMT2ALMNAMAPT | |
| SCHEMBL5594962 | 0.83 | MEN1 (0.72) | HTTDDX3XKMT2ALMNAMAPT | |
| SCHEMBL16592441 | 0.83 | PKM (0.78) | HTTPKMKMT2ALMNAMAPT | |
| SCHEMBL16592442 | 0.83 | PKM (0.78) | HTTPKMKMT2ALMNAMAPT | |
| SCHEMBL6820169 | 0.82 | KMT2A (0.68) | HTTPKMKMT2ALMNAMAPT | |
| SCHEMBL3710415 | 0.82 | KMT2A (0.68) | HTTPKMKMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173415-A1 | DIPHENYLUREA DERIVATIVES | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064866-A1 | DIPHENYLUREA DERIVATIVES | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | disclosed |