Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7408740 | 0.90 | METAP1 (0.40) | METAP1NAMPTCYP17A1ATRKDM4E | |
| SCHEMBL7419909 | 0.88 | METAP1 (0.39) | METAP1NAMPTCYP17A1ATRKDM4E | |
| SCHEMBL29919808 | 0.88 | METAP1 (0.45) | METAP1NAMPTCYP17A1ATRKDM4E | |
| SCHEMBL69347 | 0.88 | METAP1 (0.45) | METAP1NAMPTCYP17A1ATRKDM4E | |
| SCHEMBL16766552 | 0.87 | KDM4E (0.47) | METAP1NAMPTCYP17A1ATRKDM4E | |
| SCHEMBL7410155 | 0.86 | LMNA (0.39) | METAP1KDM4EL3MBTL1 | |
| SCHEMBL2696598 | 0.85 | GRM5 (0.46) | METAP1NAMPTCYP17A1ATRKDM4E | |
| SCHEMBL28028757 | 0.85 | MAPT (0.44) | METAP1NAMPTCYP17A1KDM4EL3MBTL1 | |
| SCHEMBL27703346 | 0.84 | METAP1 (0.44) | METAP1NAMPTCYP17A1ATRKDM4E | |
| SCHEMBL30450099 | 0.83 | METAP1 (0.42) | METAP1NAMPTCYP17A1ATRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |