Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 2/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214488 | 0.84 | HPGD (0.53) | XDHHPGDALDH1A1KDM4ELMNA | |
| SCHEMBL3031256 | 0.82 | HPGD (0.46) | XDHHPGDALDH1A1KDM4ELMNA | |
| SCHEMBL18661924 | 0.82 | IDO1 (0.46) | HPGDALDH1A1KDM4ELMNAHSD17B10 | |
| SCHEMBL3543391 | 0.82 | DAO (0.46) | HPGDALDH1A1KDM4ELMNAHSD17B10 | |
| SCHEMBL3708783 | 0.82 | XDH (0.69) | XDHHPGDALDH1A1KDM4ELMNA | |
| SCHEMBL16571035 | 0.78 | DAO (0.43) | XDHHPGDALDH1A1KDM4ELMNA | |
| SCHEMBL16571479 | 0.78 | XDH (0.42) | XDHHPGDALDH1A1KDM4ELMNA | |
| SCHEMBL2660159 | 0.77 | APEX1 (0.62) | XDHHPGDALDH1A1KDM4ELMNA | |
| SCHEMBL3722103 | 0.76 | HSD17B10 (0.60) | HPGDALDH1A1KDM4ELMNAHSD17B10 | |
| SCHEMBL15340715 | 0.76 | FBP1 (0.47) | XDHHPGDALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5547991-A | NMDA antagonism method | MERRELL PHARMACEUTICALS INC. (US) | 1996-08-20 | — | — | US | disclosed |
| US-5484814-A | NMDA antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-01-16 | — | — | US | disclosed |
| US-5470870-A | New class of excitatory amino acid antagonist for epilepsy, anxiety or stroke | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0501378-B1 | NMDA Antagonists | MERRELL DOW PHARMA (US) | 1995-01-11 | — | — | EP | disclosed |
| US-5360814-A | NMDA antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-11-01 | — | — | US | disclosed |
| EP-0501378-A1 | NMDA Antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-02 | — | — | EP | disclosed |