SCHEMBL7410189

SCHEMBL7410189

CC1=C(C(=O)O)[C@@H](c2csc3ccncc23)C([N+](=O)[O-])=C(C)N1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.39
CACNA1C Q13936 5/20 0.39
CYP1A2 P05177 4/20 0.39
CYP3A4 P08684 4/20 0.39
ADORA3 P0DMS8 4/20 0.39
CYP2C9 P11712 4/20 0.39
CYP2C19 P33261 4/20 0.39
KMT2A Q03164 4/20 0.39
TSHR P16473 3/20 0.39
NFKB1 P19838 3/20 0.39
CYP2D6 P10635 2/20 0.39
MEN1 O00255 2/20 0.39
BACE1 P56817 3/20 0.35
CYP2A6 P11509 1/20 0.35
CACNA1B Q00975 5/20 0.35
ALDH1A1 P00352 2/20 0.33
HPGD P15428 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
KDM4E B2RXH2 1/20 0.33
ABCC4 O15439 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7409728 1.00 MAPT (0.39) MAPTCACNA1CCYP1A2CYP3A4ADORA3
SCHEMBL7407834 1.00 MAPT (0.39) MAPTCACNA1CCYP1A2CYP3A4ADORA3
SCHEMBL10372051 0.88 CYP2A6 (0.42) MAPTCACNA1CKMT2AMEN1BACE1
SCHEMBL29389135 0.86 MAPT (0.54) MAPTCACNA1CCYP1A2CYP3A4ADORA3
SCHEMBL29389617 0.84 CACNA1C (0.42) MAPTCACNA1CCYP1A2CYP3A4ADORA3
SCHEMBL29388969 0.84 MAPT (0.46) MAPTCACNA1CCYP1A2CYP3A4ADORA3
SCHEMBL29390127 0.84 MAPT (0.46) MAPTCACNA1CCYP1A2CYP3A4ADORA3
SCHEMBL29389652 0.84 MAPT (0.46) MAPTCACNA1CCYP1A2CYP3A4ADORA3
SCHEMBL29386583 0.83 CACNA1C (0.44) MAPTCACNA1CCYP1A2CYP3A4ADORA3
SCHEMBL29819617 0.83 CACNA1C (0.41) MAPTCACNA1CCYP1A2CYP3A4ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140088056-A1 CARDIAC GLYCOSIDES ARE POTENT INHIBITORS OF INTERFERON-BETA GENE EXPRESSION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2014-03-27 US claimed
WO-2012050884-A2 CARDIAC GLYCOSIDES ARE POTENT INHIBITORS OF INTERFERON-BETA GENE EXPRESSION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-04-19 WO claimed
US-11963964-B2 Small molecules for mouse satellite cell proliferation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2024-04-23 US disclosed
US-20220054499-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2022-02-24 US disclosed
US-11026952-B2 Small molecules for mouse satellite cell proliferation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2021-06-08 US disclosed
US-20200352957-A1 SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2020-11-12 US disclosed
US-10660902-B2 Method of increasing satellite cell proliferation with an HDAC inhibitor PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2020-05-26 US disclosed
EP-3411040-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION President and Fellows of Harvard College (US) 2018-12-12 EP disclosed
US-20180153902-A1 SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION HOWARD HUGHES MEDICAL INSTITUTE 2018-06-07 US disclosed
US-9782417-B2 Methods of increasing satellite cell proliferation with kinase inhibitors PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) 2017-10-10 US disclosed
WO-2017136480-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2017-08-10 WO disclosed
US-9248185-B2 Methods of increasing satellite cell proliferation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2016-02-02 US disclosed
US-20140294855-A1 SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2014-10-02 US disclosed
US-20140088056-A1 CARDIAC GLYCOSIDES ARE POTENT INHIBITORS OF INTERFERON-BETA GENE EXPRESSION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2014-03-27 US disclosed
EP-2646107-A2 AGENT DELIVERY SYSTEMS FOR SELECTIVE NEUROMODULATION Spinal Modulation Inc. (US) 2013-10-09 EP disclosed
WO-2012174537-A2 SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-12-20 WO disclosed
US-20120310140-A1 DIRECTED DELIVERY OF AGENTS TO NEURAL ANATOMY SPINAL MODULATION, INC. (US) 2012-12-06 US disclosed
WO-2012075337-A2 DIRECTED DELIVERY OF AGENTS TO NEURAL ANATOMY SPINAL MODULATION, INC. (US) 2012-06-07 WO disclosed
WO-2012050884-A2 CARDIAC GLYCOSIDES ARE POTENT INHIBITORS OF INTERFERON-BETA GENE EXPRESSION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-04-19 WO disclosed
US-4902694-A TREATING CONGESTIVE HEART FAILURE ELI LILLY AND COMPANY (US) 1990-02-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11026952-B2 Small molecules for mouse satellite cell proliferation MKI67, MYLK2, MYH2 MAPT 4150/4885CACNA1C 2996/4885CYP1A2 4849/4885
US-10660902-B2 Method of increasing satellite cell proliferation with an HDAC inhibitor HDAC4, HDAC1, HDAC5 MAPT 3910/4885CACNA1C 3447/4885CYP1A2 4694/4885
US-20220054499-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION MKI67, MYLK2, MYH2 MAPT 4150/4885CACNA1C 2996/4885CYP1A2 4849/4885
US-20180153902-A1 SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION MKI67, MYLK2, MYH2 MAPT 4009/4885CACNA1C 2730/4885CYP1A2 4811/4885
US-11963964-B2 Small molecules for mouse satellite cell proliferation MKI67, MYLK2, MYH2 MAPT 4150/4885CACNA1C 2996/4885CYP1A2 4849/4885
US-20200352957-A1 SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION MKI67, MYLK2, MYH2 MAPT 4009/4885CACNA1C 2730/4885CYP1A2 4811/4885
US-20140294855-A1 SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION MKI67, MYLK2, MYH2 MAPT 3922/4885CACNA1C 2559/4885CYP1A2 4795/4885
US-20140088056-A1 CARDIAC GLYCOSIDES ARE POTENT INHIBITORS OF INTERFERON-BETA GENE EXPRESSION IRF3, IFNG, STING1 MAPT 4814/4885CACNA1C 154/4885CYP1A2 2870/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.