Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.75 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.71 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.71 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.71 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.71 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.71 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.71 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.70 |
| ▸ | HTR2C | P28335 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19837655 | 0.94 | DRD2 (0.90) | DRD2DRD3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL19837643 | 0.94 | DRD2 (0.90) | DRD2DRD3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL13753861 | 0.91 | DRD2 (0.84) | DRD2DRD3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL27550290 | 0.91 | AKR1C3 (0.86) | DRD2DRD3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL5092794 | 0.87 | KDM4E (1.00) | DRD2DRD3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL6481636 | 0.86 | AKR1C3 (0.97) | DRD2DRD3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL6481327 | 0.86 | KDM4E (0.77) | DRD2DRD3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL9397179 | 0.85 | DRD2 (0.74) | DRD2DRD3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL6483696 | 0.84 | AKR1C3 (1.00) | DRD2DRD3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL6475055 | 0.84 | AKR1C3 (0.76) | DRD2DRD3KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129424-B2 | Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders | ATHERSYS, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110059966-A1 | INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS | BENNANI YOUSSEF L | 2011-03-10 | — | — | US | disclosed |
| US-7855224-B2 | Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders | ATHERSYS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-20090036446-A1 | Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders | BENNANI YOUSSEF L | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036446-A1 | Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders | HRH3, HCRTR1, HCRTR2 | DRD2 97/4885DRD3 66/4885KDM4E 447/4885 |
| US-20110059966-A1 | INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS | HRH3, HCRTR1, HCRTR2 | DRD2 97/4885DRD3 66/4885KDM4E 447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.