Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 18/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 18/20 | 0.47 |
| ▸ | ITGAV | P06756 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418122 | 0.97 | ITGB3 (0.50) | ITGB3ITGA2B | |
| SCHEMBL7410463 | 0.90 | ITGB3 (0.38) | ITGB3ITGA2BITGAVCA12CA1 | |
| Trifluoroacetic Acid SCHEMBL7414396 | 0.87 | POLB (0.49) | ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL7414096 | 0.86 | ITGB3 (0.50) | ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL7415728 | 0.85 | ITGB3 (0.46) | ITGB3ITGA2BITGAVCA12CA1 | |
| Trifluoroacetic Acid SCHEMBL7412868 | 0.85 | ITGB3 (0.47) | ITGB3ITGA2BITGAV | |
| Trifluoroacetic Acid SCHEMBL7415198 | 0.84 | ITGB3 (0.63) | ITGB3ITGA2BITGAV | |
| Trifluoroacetic Acid SCHEMBL7414224 | 0.84 | ITGB3 (0.47) | ITGB3ITGA2BITGAV | |
| Trifluoroacetic Acid SCHEMBL7412715 | 0.84 | ITGB3 (0.47) | ITGB3ITGA2BITGAVCA12CA1 | |
| Trifluoroacetic Acid SCHEMBL7417977 | 0.84 | ITGB3 (0.46) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | disclosed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |