Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 4/20 | 0.64 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.61 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.61 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.54 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.54 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413944 | 1.00 | CHRNA3 (0.64) | CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7827655 | 0.99 | CHRNA3 (0.63) | CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7827784 | 0.99 | CHRNA3 (0.63) | CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL7826052 | 0.92 | CHRNB4 (0.72) | CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL7817031 | 0.92 | CHRNB4 (0.72) | CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7452766 | 0.91 | CHRNB4 (0.71) | CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7823806 | 0.91 | CHRNB4 (0.71) | CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7816209 | 0.91 | CHRNB4 (0.71) | CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL7824609 | 0.87 | CHRNA3 (0.63) | CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL7817366 | 0.87 | CHRNA3 (0.63) | CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950057-B1 | 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS | ABBOTT LAB (US) | 2002-11-13 | — | — | EP | claimed |
| EP-0846114-B1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2001-12-05 | — | — | EP | claimed |
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | claimed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | claimed |
| EP-0950057-B1 | 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS | ABBOTT LAB (US) | 2002-11-13 | — | — | EP | disclosed |
| EP-0846114-B1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2001-12-05 | — | — | EP | disclosed |