SCHEMBL7817366

SCHEMBL7817366

Cc1cc(OC[C@@H]2CCN2C)cnc1Cl

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA3 P32297 5/20 0.63
CHRNB4 P30926 4/20 0.57
CHRNA7 P36544 1/20 0.57
CHRNB2 P17787 4/20 0.53
CHRNA4 P43681 4/20 0.53
CHRNB1 P11230 3/20 0.53
CHRNB3 Q05901 3/20 0.53
DAPK3 O43293 1/20 0.51
ROCK2 O75116 1/20 0.51
PRKCG P05129 1/20 0.51
PIM1 P11309 1/20 0.51
RPS6KB1 P23443 1/20 0.51
AKT1 P31749 1/20 0.51
LIMK1 P53667 1/20 0.51
CDK5 Q00535 1/20 0.51
PRKCD Q05655 1/20 0.51
PAK1 Q13153 1/20 0.51
STK3 Q13188 1/20 0.51
ROCK1 Q13464 1/20 0.51
DYRK1A Q13627 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7824609 1.00 CHRNA3 (0.63) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL7825587 0.92 CHRNB4 (0.67) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL7827114 0.92 CHRNB4 (0.67) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL7413944 0.87 CHRNA3 (0.64) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL7410468 0.87 CHRNA3 (0.64) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
Hydrochloric Acid SCHEMBL7827784 0.86 CHRNA3 (0.63) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
Hydrochloric Acid SCHEMBL7827655 0.86 CHRNA3 (0.63) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL7828152 0.86 CHRNA3 (0.58) CHRNA3CHRNB4CHRNB2CHRNA4CHRNB1
SCHEMBL7825054 0.86 CHRNA3 (0.58) CHRNA3CHRNB4CHRNB2CHRNA4CHRNB1
SCHEMBL7410204 0.85 CHRNA3 (0.61) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0846114-B1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2001-12-05 EP claimed
EP-0846114-B1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2001-12-05 EP disclosed